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THESIS_KHALED_ALAYED_012519.pdf (1.98 MB)

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MULTIOMICS EVALUATION OF THE EFFECT OF EZRIN INHIBITOR IN DIFFUSE LARGE B CELL LYMPHOMA REVEALS DYSREGULATION OF BCR SIGNALING, RHO GTPASE SIGNALING AND APOPTOSIS

Alayed, Khaled
http://rave.ohiolink.edu/etdc/view?acc_num=case1552485811716089

Abstract Details

, Master of Sciences, Case Western Reserve University, Systems Biology and Bioinformatics.
Activated B-cell like diffuse large B-cell lymphoma (ABC-DLBCL) is one of two molecular subtypes of DLBCL. ABC-DLBCL exhibits worse outcome following standard therapy. The pathogenesis of ABC-DLBCL is due to constitutive activation of NF-κB signaling pathway which lead to activation of numerous of processes like cell proliferation and survival. Recently, findings indicate ezrin inhibitors (Ez-Is), NSC305787 and NSC668394, were found to disrupt BCR signaling and decrease pro-survival signaling through induction of apoptosis. To gain more insights into the mechanism of action of Ez-Is in ABC-DLBCL, we performed a multiomics analysis of RNA microarray, protein and phosphoprotein mass spectrometry (MS) from ABC-DLBCL cell lines treated with Ez-I. Our results revealed Ez-I affect many genes, protein and phosphoproteins. The pathway enrichment of them showed pathways mainly related to BCR signaling, Rho GTPase signaling and apoptosis are affected. Our findings were similar to published data and increased our understanding of Ez-I in ABC-DLBCL.
Gurkan Bebek (Committee Chair)
Masaru Miyagi (Committee Member)
Neetu Gupta (Committee Member)
Bioinformatics

Recommended Citations

Citations

  • Alayed, K. (n.d.). MULTIOMICS EVALUATION OF THE EFFECT OF EZRIN INHIBITOR IN DIFFUSE LARGE B CELL LYMPHOMA REVEALS DYSREGULATION OF BCR SIGNALING, RHO GTPASE SIGNALING AND APOPTOSIS [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1552485811716089

    APA Style (7th edition)

  • Alayed, Khaled. MULTIOMICS EVALUATION OF THE EFFECT OF EZRIN INHIBITOR IN DIFFUSE LARGE B CELL LYMPHOMA REVEALS DYSREGULATION OF BCR SIGNALING, RHO GTPASE SIGNALING AND APOPTOSIS. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1552485811716089.

    MLA Style (8th edition)

  • Alayed, Khaled. "MULTIOMICS EVALUATION OF THE EFFECT OF EZRIN INHIBITOR IN DIFFUSE LARGE B CELL LYMPHOMA REVEALS DYSREGULATION OF BCR SIGNALING, RHO GTPASE SIGNALING AND APOPTOSIS." Master's thesis, Case Western Reserve University. Accessed MAY 11, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1552485811716089

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.