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Dual Delivery of Anti-inflammatory and Anti-microbial Drugs from Affinity Polymer Coated Sutures Parallels Wound Healing Timeline

Haley, Rebecca M
http://orcid.org/0000-0001-7322-7829
http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362

Abstract Details

2019, Master of Sciences (Engineering), Case Western Reserve University, Biomedical Engineering.
Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing. The development of a polymerized cyclodextrin (pCD) coated surgical suture introduces the capability to locally deliver both anti-inflammatory and anti-microbial drugs throughout the phases of acute and chronic healing. Local delivery allows for the improvement of wound healing while reducing related systemic side effects and drug resistance. Through testing, it has been shown that the fabrication of this pCD coating minimally affects the suture’s mechanical properties. In-vitro studies show measurable and consistent drug delivery for nearly five weeks. The therapeutic level of this delivery is sufficient to show inhibition of bacterial growth for four weeks, and free-radical scavenging (an in-vitro anti-inflammatory activity approximation) for two weeks. With this pCD coating technique, we maintain clinical performance standards while also introducing a long-term dual delivery system relevant to the wound healing timeframe.
Horst von Recum (Advisor)
Anirban Sen Gupta (Committee Member)
Agata Exner (Committee Member)
50 p.
Biomedical Engineering; Biomedical Research; Engineering
Drug Delivery; Infection; Inflammation; Suture; Wound Healing; Cyclodextrin; Polymer; Hydrogel

Recommended Citations

Citations

  • Haley, R. M. (2019). Dual Delivery of Anti-inflammatory and Anti-microbial Drugs from Affinity Polymer Coated Sutures Parallels Wound Healing Timeline [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362

    APA Style (7th edition)

  • Haley, Rebecca. Dual Delivery of Anti-inflammatory and Anti-microbial Drugs from Affinity Polymer Coated Sutures Parallels Wound Healing Timeline. 2019. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362.

    MLA Style (8th edition)

  • Haley, Rebecca. "Dual Delivery of Anti-inflammatory and Anti-microbial Drugs from Affinity Polymer Coated Sutures Parallels Wound Healing Timeline." Master's thesis, Case Western Reserve University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1554346416846362

    Chicago Manual of Style (17th edition)

case1554346416846362
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© 2019, some rights reserved.Creative Commons License Dual Delivery of Anti-inflammatory and Anti-microbial Drugs from Affinity Polymer Coated Sutures Parallels Wound Healing Timeline by Rebecca M Haley is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.