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Integrative 'Omics Approach to Investigate Relationship Between COPD and Lung Cancer

Skander, Dannielle

Abstract Details

, Master of Sciences, Case Western Reserve University, Systems Biology and Bioinformatics.
Chronic obstructive pulmonary disease (COPD) and lung cancer are among the leading causes of death worldwide. While it is believed the two diseases are related, the mechanisms behind this relationship remain unclear. In this work, we will investigate the relationship between COPD and lung cancer using an integrative `omics approach. The advantage of using this approach, rather than single `omics, is that integration of epigenetic and gene expression data allows us to discover the functionally relevant genes, i.e., the genes crucial for disease development. Using this approach, our study suggests that the mechanisms driving the development of both diseases are related to the interleukin immune response (IL4 and IL17) and PTEN and PI3K-AKT pathways. Understanding this relationship between COPD and lung cancer is crucial for future prevention and treatment options of both COPD and lung cancer.
Gurkan Bebek (Advisor)
Cheryl Cameron (Committee Chair)
Mohammad Shatat (Committee Chair)

Recommended Citations

Citations

  • Skander, D. (n.d.). Integrative 'Omics Approach to Investigate Relationship Between COPD and Lung Cancer [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1559950959673037

    APA Style (7th edition)

  • Skander, Dannielle. Integrative 'Omics Approach to Investigate Relationship Between COPD and Lung Cancer. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1559950959673037.

    MLA Style (8th edition)

  • Skander, Dannielle. "Integrative 'Omics Approach to Investigate Relationship Between COPD and Lung Cancer." Master's thesis, Case Western Reserve University. Accessed MARCH 29, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=case1559950959673037

    Chicago Manual of Style (17th edition)