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Thesis 040720.pdf (1.06 MB)

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Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss

Lu, Chao-yi
http://orcid.org/0000-0002-3486-7804
http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386

Abstract Details

2020, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Antibiotic-loaded poly(methyl methacrylate) (PMMA) cement is commonly used as a local delivery system to treat and prevent orthopedic infections associated with arthroplasties in load-bearing applications. However, these delivery systems are inefficient as release rate sharply declines to subinhibitory levels. Prior studies have shown that by adding in drug-filled cyclodextrin (CD) microparticles into PMMA cement, a more consistent release was observed. Additionally, antibiotic refilling through simulated implantation was achieved, but a loss in mechanical properties was noticed. In order to decrease the mechanical loss, modified CD microparticles (PMMA-CD) were synthesized. The compressive strengths, handling characteristics, and refilling ability of PMMA with PMMA-CD were evaluated. Up to a 10% increase in compressive strength was observed when CD was substituted with PMMA-CD. A longer working time and lower maximum temperature were observed with both the addition of CD and of PMMA-CD into PMMA, and refilling was also observed in PMMA with PMMA-CD.
Horst von Recum, PhD (Advisor)
Agata Exner, PhD (Committee Member)
Jon Pokorski, PhD (Committee Member)
60 p.
Biomedical Engineering
Drug delivery; orthopedic infection; polymer; cyclodextrin; PMMA

Recommended Citations

Citations

  • Lu, C.-Y. (2020). Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386

    APA Style (7th edition)

  • Lu, Chao-yi. Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss. 2020. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386.

    MLA Style (8th edition)

  • Lu, Chao-yi. "Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss." Master's thesis, Case Western Reserve University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1586361699051386

    Chicago Manual of Style (17th edition)

case1586361699051386
313
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.