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Deformation heterogeneity radiomics to predict molecular sub-types and overall survival in pediatric Medulloblastoma.

Iyer , Sukanya Raj
http://rave.ohiolink.edu/etdc/view?acc_num=case1588601774292049

Abstract Details

2020, Master of Sciences, Case Western Reserve University, Biomedical Engineering.
Genomic characterization of Medulloblastoma (MB), an aggressive pediatric tumor, has recently identified 4 distinct molecular subgroups: Sonic Hedgehog (SHH) , Wingless (WNT) , Group 3, Group 4 each exhibiting different clinical behavior. The molecular sub-types have unique risk-profiles and outcomes, and patients could potentially benefit from sub-group specific treatments. However, the transition of these molecular MB sub-types into clinical practice has been limited due to challenges in availability of molecular profiling in most clinics. The hypotheses we sought to examine in this preliminary study was whether computer extracted deformation features of medulloblastomas from T1-weighted MRI could independently (1) distinguish between molecularly determined subgroups, and (2) distinguish between high risk and low risk MB patient populations based on their overall survival. Our feasibility results suggest that the subtle tissue deformation features in the brain around tumor region on routine MRI may potentially serve as surrogate markers to non-invasively characterize molecular sub-types, as well as to predict survival risk in pediatric MB patients.
Pallavi Tiwari, PhD (Advisor)
Anant Madabhushi, PhD (Committee Member)
David Wilson, PhD (Committee Member)
Benita Tamrazi, MD (Committee Member)
37 p.
Biomedical Engineering
Medulloblastoma; Molecular sub-typing; Wingless; Sonic Hedgehog; Group 3; Group 4; Radiomics; Deformation; Brain; Machine Learning; Cancer; Image analysis; Survival; Prognosis; Diagnosis;

Recommended Citations

Citations

  • Iyer , S. R. (2020). Deformation heterogeneity radiomics to predict molecular sub-types and overall survival in pediatric Medulloblastoma. [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1588601774292049

    APA Style (7th edition)

  • Iyer , Sukanya Raj. Deformation heterogeneity radiomics to predict molecular sub-types and overall survival in pediatric Medulloblastoma. 2020. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1588601774292049.

    MLA Style (8th edition)

  • Iyer , Sukanya Raj. "Deformation heterogeneity radiomics to predict molecular sub-types and overall survival in pediatric Medulloblastoma." Master's thesis, Case Western Reserve University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1588601774292049

    Chicago Manual of Style (17th edition)

case1588601774292049
118
© 2020, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.