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Bridging the Gap: Developing Synthetic Materials with Enzymatic Levels of Complexity and Function

Fuller, Kristin M
http://rave.ohiolink.edu/etdc/view?acc_num=case1595941048642725

Abstract Details

2020, Master of Sciences (Engineering), Case Western Reserve University, Macromolecular Science and Engineering.
A novel approach to develop well-defined hyperbranched star polymers is presented herein. The unique three-dimensional structures were synthesized by an arm-first star polymerization route, coupled with an A2 + B3 approach that utilized the copper-catalyzed azide-alkyne cycloaddition (CuAAC). The synthesis of these new materials is relatively straight-forward, and the size of the resultant stars can be easily tuned by varying the reaction conditions. Because the synthesis is tolerant of various different functional groups, there is potential to achieve access to a large library of distinctive star polymers with differing chemical properties. In this vein, the method was used to create stars from polystyrene and polyacrylonitrile starting materials. Moving forward, the unique properties of the materials–highly soluble polymers with both peripheral functional groups and many interior "pockets" offering potential spaces for site isolation– can be used to gain a better understanding of polymer-supported catalysis. Furthermore, it is the hope that these materials are the next step in bridging the gap between the catalytic ability and functional breadth of enzymes as compared to synthetic catalysts.
Valentin Rodionov (Committee Chair)
45 p.
Organic Chemistry; Polymer Chemistry
polymer chemistry; polymer science; click chemistry; CuAAC; star polymers; hyperbranched polymers; ATRP

Recommended Citations

Citations

  • Fuller, K. M. (2020). Bridging the Gap: Developing Synthetic Materials with Enzymatic Levels of Complexity and Function [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1595941048642725

    APA Style (7th edition)

  • Fuller, Kristin. Bridging the Gap: Developing Synthetic Materials with Enzymatic Levels of Complexity and Function. 2020. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1595941048642725.

    MLA Style (8th edition)

  • Fuller, Kristin. "Bridging the Gap: Developing Synthetic Materials with Enzymatic Levels of Complexity and Function." Master's thesis, Case Western Reserve University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595941048642725

    Chicago Manual of Style (17th edition)

case1595941048642725
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This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.