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The Role of Mitochondrial Dysfunction in the Pathogenesis of Tauopathies

Horan, Katherine Erin
http://rave.ohiolink.edu/etdc/view?acc_num=case1613140812450564

Abstract Details

2021, Master of Sciences, Case Western Reserve University, Physiology and Biophysics.
The abnormal hyperphosphorylation and aggregation of tau proteins is a hallmark of tauopathies. These neurodegenerative diseases impact millions of people worldwide and yet there are no adequate therapies currently available. Mitochondrial dysfunction and mitophagy impairment have more recently been identified as contributors to the progression of age-related diseases, but their exact roles in the pathogenesis of tauopathy-type neurodegenerative diseases remains unknown. Preliminary investigations in the field yielded conflicting results that supported two different hypotheses: One identifying pathological tau as the driving force, and the other identifying mitochondrial dysfunction and mitophagy impairment as the driving force of disease progression. While the two different theories have been consolidated into the “vicious cycle” model, the field is left with many questions related to what causes the onset of tauopathies. This review summarizes the connections between mitochondrial dysfunction and the pathogenesis of tauopathy-type neurodegenerative diseases. Additionally, this review covers how the roles of mitochondrial dysfunction and mitophagy impairment are currently being applied to the development of therapeutics.
Xin Qi, Ph.D. (Advisor)
George Dubyak, Ph.D. (Committee Chair)
William Schilling, Ph.D. (Committee Member)
Corey Smith, Ph.D. (Committee Member)
36 p.
Biophysics; Philosophy
Mitochondria; Tauopathy; Mitochondrial dysfunction; Mitophagy; Tau

Recommended Citations

Citations

  • Horan, K. E. (2021). The Role of Mitochondrial Dysfunction in the Pathogenesis of Tauopathies [Master's thesis, Case Western Reserve University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=case1613140812450564

    APA Style (7th edition)

  • Horan, Katherine. The Role of Mitochondrial Dysfunction in the Pathogenesis of Tauopathies . 2021. Case Western Reserve University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=case1613140812450564.

    MLA Style (8th edition)

  • Horan, Katherine. "The Role of Mitochondrial Dysfunction in the Pathogenesis of Tauopathies ." Master's thesis, Case Western Reserve University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1613140812450564

    Chicago Manual of Style (17th edition)

case1613140812450564
267
© 2021, all rights reserved.
This open access ETD is published by Case Western Reserve University School of Graduate Studies and OhioLINK.