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The Effect of DBS Settings on Neuropsychological Functioning in Patients with Parkinson's Disease

Mash, Kathleen M
http://rave.ohiolink.edu/etdc/view?acc_num=csu1199728007

Abstract Details

2007, Master of Arts in Psychology, Cleveland State University, College of Science.
Parkinson’s disease (PD) is an idiopathic progressive neurological disorder. Improvement in Parkinsonian motor function has been established with subthalamic nucleus (STN) deep brain stimulation (DBS). Recently, the relationship between DBS stimulator settings and motor function has begun to be explored; however, no study to date has investigated the relationship between DBS settings and neuropsychological functioning. This study evaluated the extent to which DBS settings (i.e., amplitude, frequency, and pulse width) are associated with post-operative performances on the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status). The study was a prospective clinical trial of STN DBS for the treatment of medication refractory PD. Twenty patients were identified that met study inclusion and exclusion criteria. All participants completed neuropsychological evaluations, including the RBANS. Correlations revealed significant relationships between amplitude and pulse width with RBANS indices of visuospatial/constructional ability (r =.55) and immediate memory (r = .45). Also, significant relationships were found between amplitude and line orientation (r =.45) and pulse width and delayed figure recall (r =.46). Multiple regression found DBS stimulator settings, along with symptoms of anxiety, to be significant predictors of RBANS scores. While DBS appears to be relatively benign from a neuropsychological standpoint, some patients experience more pronounced impairments. One variable that may account for previous variability is DBS stimulation parameters.
Steve Slane (Advisor)
76 p.
Psychology, Clinical
Parkinson's Disease; Deep Brain Stimulation

Recommended Citations

Citations

  • Mash, K. M. (2007). The Effect of DBS Settings on Neuropsychological Functioning in Patients with Parkinson's Disease [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1199728007

    APA Style (7th edition)

  • Mash, Kathleen. The Effect of DBS Settings on Neuropsychological Functioning in Patients with Parkinson's Disease. 2007. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1199728007.

    MLA Style (8th edition)

  • Mash, Kathleen. "The Effect of DBS Settings on Neuropsychological Functioning in Patients with Parkinson's Disease." Master's thesis, Cleveland State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=csu1199728007

    Chicago Manual of Style (17th edition)

csu1199728007
929
© 2007, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.