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Quadrupole Magnetic Field-Flow Fractionation: A Novel Technique For The Characterization Of Magnetic Particles

Carpino, Francesca
http://rave.ohiolink.edu/etdc/view?acc_num=csu1207595560

Abstract Details

2008, Doctor of Philosophy in Clinical-Bioanalytical Chemistry, Cleveland State University, College of Science.
In the last few decades, the development and use of nanotechnology has become of increasing importance. Magnetic nanoparticles, because of their unique properties, have been employed in many different areas of application. They are generally made of a core of magnetic material coated with some other material to stabilize them and to help disperse them in suspension. The unique feature of magnetic nanoparticles is their response to a magnetic field. They are generally superparamagnetic, in which case they become magnetized only in a magnetic field and lose their magnetization when the field is removed. It is this feature that makes them so useful for drug targeting, hyperthermia and bioseparation. For many of these applications, the synthesis of uniformly sized magnetic nanoparticles is of key importance because their magnetic properties depend strongly on their dimensions. Because of the difficulty of synthesizing monodisperse particulate materials, a technique capable of characterizing the magnetic properties of polydisperse samples is of great importance. Quadrupole magnetic field-flow fractionation (MgFFF) is a technique capable of fractionating magnetic particles based on their content of magnetite or other magnetic material. In MgFFF, the interplay of hydrodynamic and magnetic forces separates the particles as they are carried along a separation channel. Since the magnetic field and the gradient in magnetic field acting on the particles during their migration are known, it is possible to calculate the quantity of magnetic material in the particles according to their time of emergence at the channel outlet. Knowing the magnetic properties of the core material, MgFFF can be used to determine both the size distribution and the mean size of the magnetic cores of polydisperse samples. When magnetic material is distributed throughout the volume of the particles, the derived data corresponds to a distribution in equivalent spherical diameters of magnetic material in the particles. MgFFF is unique in its ability to characterize the distribution in magnetic properties of a particulate sample. This knowledge is not only of importance to the optimization and quality control of particle preparation. It is also of great importance in modeling magnetic cell separation, drug targeting, hyperthermia, and other areas of application.
Dr. P.Stephen Williams (Committee Chair)
Dr. Aaron Fleischman (Committee Member)
Dr. John Turner (Advisor)
Dr. Yan Xu (Committee Member)
Dr. Maciej Zborowski (Committee Member)
141 p.
Chemistry
magnetization; magnetic field; PARTICLES; elution; nanoparticles; MgFFF

Recommended Citations

Citations

  • Carpino, F. (2008). Quadrupole Magnetic Field-Flow Fractionation: A Novel Technique For The Characterization Of Magnetic Particles [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207595560

    APA Style (7th edition)

  • Carpino, Francesca. Quadrupole Magnetic Field-Flow Fractionation: A Novel Technique For The Characterization Of Magnetic Particles. 2008. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1207595560.

    MLA Style (8th edition)

  • Carpino, Francesca. "Quadrupole Magnetic Field-Flow Fractionation: A Novel Technique For The Characterization Of Magnetic Particles." Doctoral dissertation, Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1207595560

    Chicago Manual of Style (17th edition)

csu1207595560
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© 2008, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.