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Imaging of Tyramine-Substituted Hydrogels for Tissue Replacement

Laurens, Ediuska V.
http://rave.ohiolink.edu/etdc/view?acc_num=csu1265639619

Abstract Details

2009, Doctor of Engineering, Cleveland State University, Fenn College of Engineering.
Novel tyramine-based hyaluronan (HA) and collagen hydrogels have been developed in which cross-linking is accomplished via peroxidase-mediated dityramine linkages allowing direct cross-linking in vivo. These TB hydrogels possess advantageous physical properties, which include excellent biocompatibility and the ability to mimic the biological, structural and mechanical properties of normal, healthy tissues, including cartilage, and thus provide for synthetic, implantable biomaterials suitable for a wide range of tissue types. The efficacy of these TB-hydrogels has been previously tested in a number of clinically relevant animal models, which have evaluated their applicability for the repair/replacement of various tissues, including cartilage. Nevertheless, there exists a fundamental need for non-destructive methods to identify, distinguish, quantify and trace these biomaterials in vivo. Magnetic Resonance Imaging (MRI) is a broadly used non-invasive clinical imaging methodology that allows direct visualization of soft tissues. Our results indicated that T1 and T2 mapping can differentiate and measure changes in HA and collagen concentration both alone and in combination with composite materials, composed of HA and collagen at the concentrations found in cartilage resulting in T1 values representative of cartilage. Furthermore, the dGEMRIC technique was able to quantify the HA concentration in phantoms of known HA concentration. These MRI techniques could detect and differentiate the tyramine-based hydrogels in implanted joints, and accurately quantify their volumes.
Anthony Calabro, PhD (Committee Chair)
Nolan Holland, PhD (Committee Co-Chair)
Lars Gilbertson, PhD (Committee Member)
Mark Kayanja, MD, PhD (Committee Member)
Miron Kaufman, PhD (Committee Member)
261 p.
Biomedical Research; Materials Science; Polymers
Hyaluronan Hydrogels; Collagen Hydrogels; MRI; T1 map; T2 map

Recommended Citations

Citations

  • Laurens, E. V. (2009). Imaging of Tyramine-Substituted Hydrogels for Tissue Replacement [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1265639619

    APA Style (7th edition)

  • Laurens, Ediuska. Imaging of Tyramine-Substituted Hydrogels for Tissue Replacement. 2009. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1265639619.

    MLA Style (8th edition)

  • Laurens, Ediuska. "Imaging of Tyramine-Substituted Hydrogels for Tissue Replacement." Doctoral dissertation, Cleveland State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1265639619

    Chicago Manual of Style (17th edition)

csu1265639619
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© 2010, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.