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RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT

Shuster, Jaime Lynn
http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196

Abstract Details

2011, Master of Arts in Psychology, Cleveland State University, College of Sciences and Health Professions.
Traumatic brain injury (TBI) resulting from bomb blasts and explosions is common among military personnel. The effects of Rapid Eye Movement (REM) sleep deprivation on the sensorimotor behavior and physiological mechanisms related to TBI are unknown. Thirty-two Long Evans rats were randomly assigned to REM sleep deprivation (RSD) with controlled cortical impact (CCI), social isolation (SI) with CCI, or normal housing (NH) with CCI or Sham. Two behavioral tasks [beam walk and bilateral tactile adhesive removal somatosensory (BTARS)] testing motor and sensory function were used to investigate recovery of function. Brain tissue was analyzed using Cresyl Violet stain (cell bodies), GFAP (astrocytes) and Fluoro Jade-B (dying cells) labeling. Results indicated that 24 hour RSD immediately prior to CCI impaired recovery of sensorimotor function when tested on the adhesive removal task. Recovery of sensorimotor function as a result of 24 hour RSD immediately prior to CCI was not significantly impaired when tested on the balance beam walk task. Results also indicated that sleep deprivation seemed to intensify inflammation, lesion size and neuron loss when compared to non sleep deprived animals.
Stephen Slane, PhD (Committee Chair)
Sherry Ball, PhD (Advisor)
Michael Hammonds, PhD (Committee Member)
65 p.
Animal Sciences; Animals; Biochemistry; Biology; Experimental Psychology; Psychobiology; Psychology
Traumatic Brain Injury (TBI); Sleep deprivation; Sensorimotor; Controlled Cortical Impact (CCI)

Recommended Citations

Citations

  • Shuster, J. L. (2011). RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196

    APA Style (7th edition)

  • Shuster, Jaime. RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT. 2011. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196.

    MLA Style (8th edition)

  • Shuster, Jaime. "RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT." Master's thesis, Cleveland State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1301676196

    Chicago Manual of Style (17th edition)

csu1301676196
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© 2011, some rights reserved.Creative Commons License RECOVERY OF SENSORIMOTOR FUNCTION IN RATS FOLLOWING ACUTE RAPID EYE MOVEMENT SLEEP DEPRIVATION AND CONTROLLED CORTICAL IMPACT by Jaime Lynn Shuster is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Cleveland State University and OhioLINK.