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Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography

Badipatla, Visweswararao
http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284

Abstract Details

2011, Master of Science in Chemistry, Cleveland State University, College of Sciences and Health Professions.
The current United States Pharmacopoeia (USP) test for tablet and encapsulated drug disintegration does not specify the initial disintegration time and provides limited information on the disintegration process itself. An isothermal Thermal Mechanical Analysis (IsoTMA) method is presented to measure the rate and initial time of drug disintegration, that is, the mechanical collapse of the gelatin capsule or the solid tablet. This method monitors changes in the dimensions of the formulated drugs during their disintegration in a liquid. Dimensional changes can be followed as a function of time, temperature, applied stress and pH. Some of the drugs studied were Olanzapine®, Ritalin® Amoxicillin® and .Graphical representations of their dimensional changes over time were compared for tablets and capsules from 25°C to 37°C and pH 3 to 7. An increase in temperature decreases the overall disintegration time and increases the rate of disintegration (mm/min). For Abilify®, pH had an appreciable effect on the rate of disintegration.
Bin Su, PhD (Committee Chair)
Alan Riga, PhD (Committee Co-Chair)
Mekki Bayachou, PhD (Committee Member)
Stan Duraj, PhD (Committee Member)
Tobili Sam Yellowe, PhD (Committee Member)
Analytical Chemistry

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Citations

  • Badipatla, V. (2011). Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284

    APA Style (7th edition)

  • Badipatla, Visweswararao. Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography. 2011. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284.

    MLA Style (8th edition)

  • Badipatla, Visweswararao. "Disintegration of Tablets and Capsules Measured by Isothermal Thermal Mechanical Analysis and Macrophotography." Master's thesis, Cleveland State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1315507284

    Chicago Manual of Style (17th edition)

csu1315507284
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© 2011, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.