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Prasath Dissertation.pdf (4.9 MB)

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IN VITRO BIOMECHANICAL TESTING AND COMPUTATIONAL MODELING IN SPINE

Prasath, Mageswaran
http://rave.ohiolink.edu/etdc/view?acc_num=csu1367503283

Abstract Details

2012, Doctor of Engineering, Cleveland State University, Fenn College of Engineering.
Two separate in vitro biomechanical studies were conducted on human cadaveric spines (Lumbar) to evaluate the stability following the implantation of two different spinal fixation devices; interspinous fixation device (ISD) and Hybrid dynamic stabilizers. ISD was evaluated as a stand-alone and in combination with unilateral pedicle rod system. The results were compared against the gold standard, spinal fusion (bilateral pedicle rod system). The second study involving the hybrid dynamic system, evaluated the effect on adjacent levels using a hybrid testing protocol. A robotic spine testing system was used to conduct the biomechanical tests. This system has the ability to apply continuous unconstrained pure moments while dynamically optimizing the motion path to minimize off-axis loads during testing. Thus enabling precise control over the loading and boundary conditions of the test. This ensures test reliability and reproducibility. We found that in flexion-extension, the ISD can provide lumbar stability comparable to spinal fusion. However, it provides minimal rigidity in lateral bending and axial rotation when used as a stand-alone. The ISD with a unilateral pedicle rod system when compared to the spinal fusion construct were shown to provide similar levels of stability in all directions, though the spinal fusion construct showed a trend toward improved stiffness overall. The results for the dynamic stabilization system showed stability characteristics similar to a solid all metal construct. Its addition to the supra adjacent level (L3- L4) to the fusion (L4- L5) indeed protected the adjacent level from excessive motion. However, it essentially transformed a 1 level into a 2 level lumbar fusion with exponential transfer of motion to the fewer remaining discs (excessive adjacent level motion). The computational aspect of the study involved the development of a spine model (single segment). The kinematic data from these biomechanical studies (ISD study) was then used to validate a finite element model of the spine.
Robert McLain (Committee Chair)
141 p.
Biomechanics; Biomedical Engineering; Biomedical Research

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Citations

  • Prasath, M. (2012). IN VITRO BIOMECHANICAL TESTING AND COMPUTATIONAL MODELING IN SPINE [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1367503283

    APA Style (7th edition)

  • Prasath, Mageswaran. IN VITRO BIOMECHANICAL TESTING AND COMPUTATIONAL MODELING IN SPINE . 2012. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1367503283.

    MLA Style (8th edition)

  • Prasath, Mageswaran. "IN VITRO BIOMECHANICAL TESTING AND COMPUTATIONAL MODELING IN SPINE ." Doctoral dissertation, Cleveland State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1367503283

    Chicago Manual of Style (17th edition)

csu1367503283
1,006
© 2012, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.