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Time and Temperature Dependent Surface Tension Measurements of Responsive Protein-based Polymer Surfactant Solutions

Abstract Details

2015, Master of Science in Biomedical Engineering, Cleveland State University, Washkewicz College of Engineering.
A three-armed star elastin-like polypeptide (ELP-foldon) has thermoreversible character which exhibits phase separation above a transition temperature (Tt) in physiologic salt concentrations. At lower salt concentration, the ELP-foldon behaves like a thermoresponsive surfactant, exhibiting micelle formation above its Tt. The purpose of this study is characterize the surfactant behavior of the ELP-foldon at air-liquid interface by measuring the surface tension. The surface tension is measured as a function of time for different ELP concentrations from 10 nM to 50 µM and over range of temperatures from 25 to 35 ¿ using the axisymmetric drop shape analysis (ADSA). The ADSA is a method which is based on the analysis of the shape and size of drop or bubble profiles to measure surface tension. It has been determined that the surface tension is not different between conditions where there are no micelles and where micelle form. Therefore, a critical micelle concentration (c.m.c.) measurement by surface tension is not meaningful. The surface tension exhibits a time-dependent reduction which can be fit with the Hua-Rosen equation. The meso-equilibrium surface pressure is ~23 mN/m and does not vary with the bulk concentration or the temperature. The time to reach the meso-equilibrium does vary with the bulk concentration. These times scale with concentration by a power of -1.2 and -1.3, suggesting that the process is not fully diffusion limited.
Nolan B. Holland, PhD (Advisor)
Sridhar Ungarala, PhD (Committee Member)
Dhananjai B. Shah, PhD (Committee Member)
83 p.

Recommended Citations

Citations

  • Celik, H. (2015). Time and Temperature Dependent Surface Tension Measurements of Responsive Protein-based Polymer Surfactant Solutions [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1440182119

    APA Style (7th edition)

  • Celik, Hakan. Time and Temperature Dependent Surface Tension Measurements of Responsive Protein-based Polymer Surfactant Solutions. 2015. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1440182119.

    MLA Style (8th edition)

  • Celik, Hakan. "Time and Temperature Dependent Surface Tension Measurements of Responsive Protein-based Polymer Surfactant Solutions." Master's thesis, Cleveland State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1440182119

    Chicago Manual of Style (17th edition)