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Menopausal Status Impairs Resistance Exercise-Induced Inflammatory Recovery

Axelrod, Christopher L
http://rave.ohiolink.edu/etdc/view?acc_num=csu1463070138

Abstract Details

2016, Master of Education, Cleveland State University, College of Education and Human Services.
Purpose: To observe the effects of menopause status on exercise-induced inflammatory responses to acute resistance exercise. Methods: Twenty women aged 18 to 65 years completed a session of submaximal, full body resistance exercise. Subjects were categorized as either pre- or post-menopausal based upon history of menopausal status and follicle stimulating hormone (FSH) levels. On a separate day prior to testing, one repetition maximums (1RM) were determined for the chest and leg press, leg curl, vertical pull down, triceps and leg extension exercise. On the day of testing, subjects performed 3 sets of 10 repetitions at 75% 1RM for all exercises. Blood samples were obtained from the antecubital vein prior to, immediately after, and one hour after the termination of exercise. Changes in plasma concentrations of IL-6, IL-10, IL-13, and TGF-ß1 were determined via enzyme-linked immunosorbent assays (ELISA). An independent t-test was used to assess basal group differences. A mixed design, repeated measures analysis of variance (ANOVA) was used to assess within and between group differences over time. Pairwise comparisons were then made from significant main effects using the Bonferroni procedure. Results: Significant (p<0.05) differences over time were found for IL-6 and IL-10. A significant (p<0.05) time by group difference was revealed for IL-10. Both groups displayed a significant one fold change in IL-6 pre to one hour post, and a half fold change immediately after to one hour post exercise. Pre-menopausal levels of IL-10 significantly increased one-fold from pre to post exercise, whereas post-menopausal levels did not significantly differ over time. Immediately post exercise IL-10 levels significantly differed between pre- (4.66 ± 1.47) and post-menopausal (1.29 ± .97) women. Conclusion: Menopausal status influenced the magnitude and time-course of the cytokine response to exercise-induced stress. Post-menopausal women exhibited an impaired capacity to resolve exercised-induced inflammation. This is consistent with several cell and animal models describing the role of estrogen in IL-10 recruitment. Thus, menopausal status, in conjunction with ageing, influenced dynamic inflammatory resolution.
Emily Kullman, Ph.D. (Committee Chair)
Kenneth Sparks, Ph.D. (Committee Co-Chair)
Kathleen Little, Ph.D. (Committee Co-Chair)
72 p.
Physiology

Recommended Citations

Citations

  • Axelrod, C. L. (2016). Menopausal Status Impairs Resistance Exercise-Induced Inflammatory Recovery [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1463070138

    APA Style (7th edition)

  • Axelrod, Christopher. Menopausal Status Impairs Resistance Exercise-Induced Inflammatory Recovery . 2016. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1463070138.

    MLA Style (8th edition)

  • Axelrod, Christopher. "Menopausal Status Impairs Resistance Exercise-Induced Inflammatory Recovery ." Master's thesis, Cleveland State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1463070138

    Chicago Manual of Style (17th edition)

csu1463070138
295
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This open access ETD is published by Cleveland State University and OhioLINK.