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Masters Thesis Morgan Miller.pdf (2.89 MB)
ETD Abstract Container
Abstract Header
State Estimation of Glucose and Insulin Dynamics
Author Info
Miller, Morgan Nicholas
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=csu1470954867
Abstract Details
Year and Degree
2016, Master of Science in Chemical Engineering, Cleveland State University, Washkewicz College of Engineering.
Abstract
Process simulation and state estimation have very important applications in chemical engineering as well as the biomedical field. Diabetes is a rapidly growing disease in the United States with 29 million people already diagnosed. The estimation of glucose and insulin concentration in patients is necessary in order to effectively treat diabetes. The Bergman Minimal Model is a popular process model that is used to simulate glucose and insulin dynamics. A simulation of this model was created based on estimated parameters for the model from historical data. This thesis investigated the estimation of glucose concentration, insulin concentration, and effect of active insulin using the extended Kalman filter, unscented Kalman filter, ensemble Kalman filter, and sequential Monte Carlo Particle filter. The performance of the filters was compared using root mean squared error. The filters were studied for the cases of good filter initialization, poor filter initialization, plant-model mismatch, increased measurement noise, and multiple glucose ingestions.
Committee
Sridhar Ungarala, PhD (Advisor)
Jorge Gatica, PhD (Committee Member)
Rolf Lustig, DRE (Committee Member)
Subject Headings
Biomedical Engineering
;
Chemical Engineering
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Citations
Miller, M. N. (2016).
State Estimation of Glucose and Insulin Dynamics
[Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1470954867
APA Style (7th edition)
Miller, Morgan.
State Estimation of Glucose and Insulin Dynamics.
2016. Cleveland State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=csu1470954867.
MLA Style (8th edition)
Miller, Morgan. "State Estimation of Glucose and Insulin Dynamics." Master's thesis, Cleveland State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1470954867
Chicago Manual of Style (17th edition)
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Document number:
csu1470954867
Download Count:
786
Copyright Info
© 2016, all rights reserved.
This open access ETD is published by Cleveland State University and OhioLINK.