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DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS

Kunati, Sandeep Reddy
http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919

Abstract Details

2018, Doctor of Philosophy in Clinical-Bioanalytical Chemistry, Cleveland State University, College of Sciences and Health Professions.
The ever-growing need to develop new anticancer agents due to increased incidence of cancer and its recurrence has led to a broad range of investigational efforts in anticancer research. Drug discovery and development processes involve evaluations of pharmacokinetic and pharmacodynamic parameters of potential drug candidates in order to assess their safety, toxicity, and efficacy profiles. By providing sensitivity, assay precision, reliability, and high-throughput, mass spectrometry has become an indispensable tool in quantitative and qualitative analysis, from early-stage drug discovery and development processes to routine laboratory analysis. Development of bioanalytical methods requires knowledge of separation science with instrumentation, data interpretation and sample preparation techniques from complex biological matrices. This work describes the theory, instrumentation, and method development processes behind these investigations. Further, detailed method development and validation procedures for investigational anticancer agents MLN0128, GS87, and curcumin using liquid chromatography-tandem mass spectrometry were presented.
Yan Xu, Ph.D. (Committee Chair)
John Turner, Ph.D. (Committee Member)
Aimin Zhou, Ph.D. (Committee Member)
Bin Su, Ph.D. (Committee Member)
Siu-Tung Yau, Ph.D. (Committee Member)
Analytical Chemistry; Chemistry

Recommended Citations

Citations

  • Kunati, S. R. (2018). DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS [Doctoral dissertation, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919

    APA Style (7th edition)

  • Kunati, Sandeep. DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS . 2018. Cleveland State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919.

    MLA Style (8th edition)

  • Kunati, Sandeep. "DEVELOPMENT OF BIOANALYTICAL METHODS FOR QUANTITATIVE MEASUREMENT OF ANTICANCER AGENTS ." Doctoral dissertation, Cleveland State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1523439107242919

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Cleveland State University and OhioLINK.