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Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation

Abdollahi Nohouji, Neda
http://rave.ohiolink.edu/etdc/view?acc_num=csu1528889736008477

Abstract Details

2018, Master of Science in Mechanical Engineering, Cleveland State University, Washkewicz College of Engineering.
Traumatic injuries and neurodengerative disease are two primary and debilitating causes of cell damage and death in the nervous system. Understanding the mechanobiological behavior of the neuron, and in particular the influence of the mechanical environment on microtubules, is integral to the prevention and treatment of many of these conditions. Within the axon, microtubules are the primary filament that provide structural support and cargo transport. The central nervous system has been a primary focus, where axonal microtubules have been studied for both traumatic brain injury [1] and many neurodegenerative diseases. Beyond the many invaluable experimental tools, modeling is a complementary tool to study the mechanics of a “bundle” of microtubules. Previous work adopted a discrete element formulation [1], though it is unclear how these assumed dynamic simulations affect modeling capabilities. A finite element (FE) based approach offers the possibility to model potentially important bending behavior (i.e. beam elements), may result in more efficient simulations, and when implemented with a co-rotational formulation [2] can account for large deformations. Hence, the goal of this work was to 1. verify implementation of a co-rotational formulation for traditional beam and truss finite elements and 2. apply the framework to predict the mechanical response of a typical microtubule bundle.
Jason Halloran (Advisor)
Richter Hanz (Committee Member)
Kothapalli Chandra (Committee Member)
73 p.
Biomechanics; Biomedical Engineering; Biomedical Research; Mechanical Engineering
Microtubule Bundle; Tau Protein; Finite Element Analysis; Co-rotational Formulation; Tension

Recommended Citations

Citations

  • Abdollahi Nohouji, N. (2018). Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1528889736008477

    APA Style (7th edition)

  • Abdollahi Nohouji, Neda. Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation. 2018. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1528889736008477.

    MLA Style (8th edition)

  • Abdollahi Nohouji, Neda. "Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation." Master's thesis, Cleveland State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1528889736008477

    Chicago Manual of Style (17th edition)

csu1528889736008477
338
© 2017, some rights reserved.Creative Commons License Evaluation of the Role of Cross-links on Microtubule Mechanics Using a Co-rotational Finite Element Simulation by Neda Abdollahi Nohouji is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Cleveland State University and OhioLINK.