Skip to Main Content
 

Global Search Box

 
 
 
 

Files

ETD Abstract Container

Abstract Header

Surface Functionalization and Optical Spectroscopy of Single-wall Carbon Nanotubes

Abstract Details

2020, Master of Science in Biomedical Engineering, Cleveland State University, Washkewicz College of Engineering.
This thesis describes a comprehensive study on the complexation of single-wall carbon nanotubes (SWCNTs) with biopolymers via noncovalent and covalent approaches as well as the characterization of the resulting complexes. SWCNTs are unique, one- dimensional nanocylinders that are highly attractive for surface modification because all their atoms comprise a surface. Specifically, single-chirality SWCNTs functionalized with biomolecules are excellent candidates for applications in bioimaging, biochemical sensing, and drug delivery. Here, we investigated the complexation affinity of recognition sequences of single-stranded DNA (ssDNA) with SWCNTs. We utilized the optical modulation of ten chirality-pure SWCNTs to study the kinetics of the coating displacement of ssDNA by a strong surfactant. Unique changes were observed for DNA- SWCNTs hybrids upon surfactant exchange, including distinct reaction time constants ranging from 9 s to 230 s and an increase in photoluminescence ranging from 1.3 to 14.7- fold. Additionally, DNA-wrapped SWCNTs showed unique interaction behavior and stability in cell culture medium. The CTC3TC-(7,6) hybrid exhibited the largest time constant upon surfactant-exchange and was the only hybrid to show an increase in near- infrared (NIR) fluorescence intensity in serum-containing cell culture medium. Moreover, we explored covalent functionalization of chirality-pure SWCNTs via oxygen doping and oriented immobilization of disaccharide lactose-containing glycopolymers. We observed a strong dependence on oxygen doping on surface-coatings of nanotubes when exposing various aqueous dispersions of SWCNTs to short wavelength ultraviolet (UV) light. Our results provide a foundation for future development of applications for chirality-pure SWCNTs in biochemical sensing and imaging advancement. Successful completion of the covalent functionalization of SWCNTs with lactose-containing glycopolymers will lead to the creation of engineered multicolor, fluorescent probes with precise optical and carbohydrate functionalities. These fluorescent probes will serve as a novel nanomaterial tool to enable better understanding of the carbohydrate-protein interactions in biology.
Geyou Ao (Advisor)
Xue-Long Sun (Committee Member)
Moo-Yeal Lee (Committee Member)
107 p.

Recommended Citations

Citations

  • Xhyliu, F. (2020). Surface Functionalization and Optical Spectroscopy of Single-wall Carbon Nanotubes [Master's thesis, Cleveland State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599143727075125

    APA Style (7th edition)

  • Xhyliu, Fjorela. Surface Functionalization and Optical Spectroscopy of Single-wall Carbon Nanotubes. 2020. Cleveland State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=csu1599143727075125.

    MLA Style (8th edition)

  • Xhyliu, Fjorela. "Surface Functionalization and Optical Spectroscopy of Single-wall Carbon Nanotubes." Master's thesis, Cleveland State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=csu1599143727075125

    Chicago Manual of Style (17th edition)