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Tapered Optical Fiber Platform for Biosensing Applications

King, Branden Joel
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398708775

Abstract Details

2014, Master of Science (M.S.), University of Dayton, Biology.
This study focuses on the design, fabrication, and characterization of tapered optical fibers for label-free, biomolecular sensing in both aqueous and gaseous environments. Single-mode fibers were tapered to a diameter of approximately 10 microns allowing for the propagation of multiple modes and creating an interference pattern in the output signal. Tapered regions serve as the sensing interface, such that the light propagating through/around the fiber interacts with molecules tethered to the tapered surface. Tapered regions are functionalized with biomolecules for capture and detection of analytes in both aqueous (antibody) and vapor phases (DNA, peptides). Molecular binding of analytes with recognition molecules changes the refractive index and the thickness of the biolayer on the fiber surface, which can be measured as a phase shift in the output spectrum. The sensing platform (fiber and Teflon flow cell) allows for fast and economical fabrication. The tapered optical fibers can be fabricated in array format for detection of multiple analytes in complex samples for biomedical (blood, saliva, breath), environmental, and homeland security applications.
Karolyn Hansen (Committee Chair)
Peter Powers (Committee Member)
Joseph Haus (Committee Member)
Mark Nielsen (Committee Member)
Amit Singh (Committee Member)
69 p.
Biology; Biomedical Engineering; Optics
biosensor; biosensing; tapered optical fiber

Recommended Citations

Citations

  • King, B. J. (2014). Tapered Optical Fiber Platform for Biosensing Applications [Master's thesis, University of Dayton]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398708775

    APA Style (7th edition)

  • King, Branden. Tapered Optical Fiber Platform for Biosensing Applications. 2014. University of Dayton, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398708775.

    MLA Style (8th edition)

  • King, Branden. "Tapered Optical Fiber Platform for Biosensing Applications." Master's thesis, University of Dayton, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1398708775

    Chicago Manual of Style (17th edition)

dayton1398708775
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© 2014, all rights reserved.
This open access ETD is published by University of Dayton and OhioLINK.