Skip to Main Content
 

Global Search Box

 
 
 

ETD Abstract Container

Abstract Header

Transition Metal Complexes of Nucleosides for Cancer Chemotherapy

Chen, Jun
http://orcid.org/0000-0002-5795-8389
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461516224

Abstract Details

2016, Master of Science (M.S.), University of Dayton, Chemistry.
Platinum(II) complexes of the type PtCl2L2, such as cisplatin---PtCl2 (NH3)2, have been widely studied and shown to have anti-tumor activity. On the other hand, ruthenium(II) complexes are known for their intense photophysical properties, biodiversity, and tumor targeting capabilities, which make them suitable as photosensitizers in photodynamic therapy. The efficacy of these complexes as anti-tumor agents is controlled by many variables such as cell permeability, availability of DNA repair processes, etc. A platinum(II)-DMSO complex and a ruthenium(II)-bypyridine complex have been incorporated into a thymidine based nucleoside through an N-3 pendant pyridyl nitrogen. Nucleosides are transported into the cell by particular trans-membrane proteins. This could increase the cellular uptake and reduce toxic side effects. Incubation of these two complexes with pUC18 circular plasmid DNA has been performed and followed by gel electrophoresis. The results show the formation of linearized forms of DNA. The structures of all intermediates and final compounds were confirmed by 1D-NMR (1H-NMR and 13C-NMR), 2D-NMR (H-C correlation, HMQC and HMBC), TOF-MS and 195Pt-NMR methodologies.
Kevin Church (Advisor)
Shawn Swavey (Committee Member)
Vladimir Benin (Committee Member)
57 p.
Chemistry
Nucleoside complex; DNA crosslinking activity; photodynamic therapy; ruthenium; transition metals

Recommended Citations

Citations

  • Chen, J. (2016). Transition Metal Complexes of Nucleosides for Cancer Chemotherapy [Master's thesis, University of Dayton]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461516224

    APA Style (7th edition)

  • Chen, Jun. Transition Metal Complexes of Nucleosides for Cancer Chemotherapy. 2016. University of Dayton, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461516224.

    MLA Style (8th edition)

  • Chen, Jun. "Transition Metal Complexes of Nucleosides for Cancer Chemotherapy." Master's thesis, University of Dayton, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1461516224

    Chicago Manual of Style (17th edition)

dayton1461516224
713
© 2016, all rights reserved.
This open access ETD is published by University of Dayton and OhioLINK.