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Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation

Kadja, Tchamie
http://orcid.org/0000-0003-3152-3771
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1556028923379642

Abstract Details

2019, Master of Science (M.S.), University of Dayton, Electrical Engineering.
Electroporation is a process that uses high voltage pulsed electric field to permeate cell membrane for drug infusion or cell death. Changing the voltage level, pulse period, or pulse width modifies the effect of the treatment. The purpose of this paper is to present a new alternative to high power pulsed field electric generators that, for the first time, reduces the system to a single custom complementary metal-oxide semiconductor (CMOS) chip, as well as allows various customizations in terms of frequency or duty cycle. A 206 kHz, 500V square wave was obtained from our chip design. The chip schematic simulation showed a duty cycle variation from 12.5% to 34.9%.
Vamsy Chodavarapu, P.E., Ph.D (Advisor)
Guru Subramanyam, Ph.D (Committee Member)
Amy Neidhard-Doll, Ph.D (Committee Member)
40 p.
Electrical Engineering
pulsed electric field; electric field generator; tunable; nanosecond; high power electric field; electroporation; system on chip; pulse period; pulse width; duty cycle; pulse frequency;

Recommended Citations

Citations

  • Kadja, T. (2019). Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation [Master's thesis, University of Dayton]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1556028923379642

    APA Style (7th edition)

  • Kadja, Tchamie. Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation . 2019. University of Dayton, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=dayton1556028923379642.

    MLA Style (8th edition)

  • Kadja, Tchamie. "Chip Scale Tunable Nanosecond Pulsed Electric Field Generator for Electroporation ." Master's thesis, University of Dayton, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1556028923379642

    Chicago Manual of Style (17th edition)

dayton1556028923379642
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© 2019, all rights reserved.
This open access ETD is published by University of Dayton and OhioLINK.