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Development of a Fluorescence Polarization Assay for Influenza Polymerase Acidic Protein Inhibitors

Kozurek, Grace
http://rave.ohiolink.edu/etdc/view?acc_num=dayton1656684628739218

Abstract Details

2022, Master of Science (M.S.), University of Dayton, Chemistry.
Influenza is a global health threat. It has been estimated by the World Health Organization that influenza is responsible for approximately 290,000-650,000 deaths, annually[1]. While there are vaccines and antiviral drugs available, there is a limit on the effectiveness of these methods of combatting the threat of influenza. Vaccines require annual updates and most of the current antivirals are experiencing an explosion of drug resistance. To improve upon these limitations, influenza’s polymerase acidic (PA) protein offers much potential as a new antiviral drug target. PA is highly conserved among various strains of influenza and plays a vital role in viral replication. Therefore, an antiviral drug that successfully targets PA will be a viable therapeutic option for a longer duration, as compared to drugs that target viral proteins with a higher amino acid variability. This thesis will showcase the process of the development of a fluorescence polarization assay to validate potential PA inhibitors for further antiviral advancements.
Doug Daniels (Advisor)
Justin Biffinger (Committee Member)
Matthew Lopper (Committee Member)
74 p.
Biochemistry; Chemistry
fluorescence polarization; assay development; polymerase acidic protein; influenza

Recommended Citations

Citations

  • Kozurek, G. (2022). Development of a Fluorescence Polarization Assay for Influenza Polymerase Acidic Protein Inhibitors [Master's thesis, University of Dayton]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1656684628739218

    APA Style (7th edition)

  • Kozurek, Grace. Development of a Fluorescence Polarization Assay for Influenza Polymerase Acidic Protein Inhibitors. 2022. University of Dayton, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=dayton1656684628739218.

    MLA Style (8th edition)

  • Kozurek, Grace. "Development of a Fluorescence Polarization Assay for Influenza Polymerase Acidic Protein Inhibitors." Master's thesis, University of Dayton, 2022. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1656684628739218

    Chicago Manual of Style (17th edition)

dayton1656684628739218
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This open access ETD is published by University of Dayton and OhioLINK.