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THE EFFICACY OF EARLY PROPRANOLOL ADMINISTRATION AT PREVENTING/REDUCING PTSD SYMPTOMS IN CHILD TRAUMA VICTIMS: PILOT

Nugent, Nicole Renee
http://rave.ohiolink.edu/etdc/view?acc_num=kent1182616758

Abstract Details

2007, PHD, Kent State University, College of Arts and Sciences / Department of Psychological Sciences.
Posttraumatic stress disorder (PTSD) in children has been associated with long-term hormonal and neuroanatomical abnormalities and serves as a risk factor for the development of PTSD following a subsequent trauma experienced in adulthood. Early psychosocial interventions designed to prevent the development of PTSD have been relatively ineffective, and research has begun to explore the efficacy of early pharmacological interventions. Recent animal and human research supports the possible use of the beta-blocker propranolol as a secondary pharmacological intervention in adults; however, the efficacy of propranolol at preventing/reducing subsequent PTSD symptoms in children has not been examined. The present investigation applied a randomized, double-blind placebo control design to the examination of the efficacy of propranolol at the prevention/reduction of PTSD symptoms in child trauma victims. It was hypothesized that children who receive propranolol, as compared with placebo recipients, would report fewer symptoms of PTSD 6-weeks post-trauma. It was also hypothesized that children in the propranolol group would show lower heart rate during recall of their trauma compared with children in the placebo group at 6-week follow-up. Analyses did not identify significant differences between participants in the placebo versus the propranolol treatment condition. However, within gender analyses revealed a different pattern of response to treatment condition, with boys showing fewer symptoms in the propranolol condition relative to the placebo condition and girls showing fewer symptoms in the placebo condition relative to the propranolol. Potential confounds, such as disproportionate assignment of family bereaved participants to the propranolol condition, pre-morbid psychopathology, and exposure to ongoing medical treatment procedures are discussed.
Douglas Delahanty (Advisor)
Psychology, Clinical
PTSD; PROPRANOLOL; TRAUMA; Medication; PTSD SYMPTOMS; SYMPTOMS; CHILD

Recommended Citations

Citations

  • Nugent, N. R. (2007). THE EFFICACY OF EARLY PROPRANOLOL ADMINISTRATION AT PREVENTING/REDUCING PTSD SYMPTOMS IN CHILD TRAUMA VICTIMS: PILOT [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1182616758

    APA Style (7th edition)

  • Nugent, Nicole. THE EFFICACY OF EARLY PROPRANOLOL ADMINISTRATION AT PREVENTING/REDUCING PTSD SYMPTOMS IN CHILD TRAUMA VICTIMS: PILOT. 2007. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1182616758.

    MLA Style (8th edition)

  • Nugent, Nicole. "THE EFFICACY OF EARLY PROPRANOLOL ADMINISTRATION AT PREVENTING/REDUCING PTSD SYMPTOMS IN CHILD TRAUMA VICTIMS: PILOT." Doctoral dissertation, Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1182616758

    Chicago Manual of Style (17th edition)

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© 2007, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.