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Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid

Zhang, Huiying
http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335

Abstract Details

2010, MS, Kent State University, College of Arts and Sciences / Department of Chemistry.
Resveratrol, a naturally occurring polyphenol found in grapevines and other plants, has been shown to have anti-cancer, anti-viral, and other activities. The specific aim of this thesis research was to evaluate and compare the antitumor activities of resveratrol alone and in combination with ascorbate against a panel of two human tumor cell lines (DU145 and MDAH) using a micro-tetrazolium (MTT) assay. Triplicate samples were assayed 12, 24, 48, and 72 hours after continuous treatments, with twelve concentrations of resveratrol and three or five combination ratios tested per time point. The FIC index, which is a marker of synergism, was calculated. Results indicated that resveratrol and ascorbate acted synergistically, reducing the time and concentrations of each component necessary to achieve an effective cytotoxicity level in hormone-independent cancer cell lines. The systematic studies and analyses of resveratrol-ascorbate combinations presented in this study have clinical significance for the evaluation and development of combination chemotherapy for the treatment of various cancer diseases.
Chun-che Tsai (Committee Chair)
Bransidhar Datta (Committee Member)
Nicola Brasch (Committee Member)
James Jamison, M (Committee Member)
56 p.
Biochemistry; Pharmaceuticals; Pharmacology
resveratrol; ascorbate; combination therapy

Recommended Citations

Citations

  • Zhang, H. (2010). Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335

    APA Style (7th edition)

  • Zhang, Huiying. Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid. 2010. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335.

    MLA Style (8th edition)

  • Zhang, Huiying. "Anticancer Activities of Resveratrol Alone and in Combination with Ascorbic Acid." Master's thesis, Kent State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271693335

    Chicago Manual of Style (17th edition)

kent1271693335
831
© 2010, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.