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Neuromodulation by G-protein-coupled receptors in the Avian Nucleus Angularis

Shi, Wei
http://rave.ohiolink.edu/etdc/view?acc_num=kent1310504010

Abstract Details

2011, MS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
The avian cochlear nucleus consists of the nucleus magnocellularis (NM) and the nucleus angularis (NA), both of which receive glutamatergic inputs from the auditory nerve. Neurons in the NM are important for processing sound timing information, whereas neurons in the NA are important for processing sound intensity information. Unlike their counterparts in the NM, neurons in the NA are heterogeneous, with several cell types being identified based on their morphology and intrinsic firing properties. Neuromodulation mediated by metabotropic glutamate and GABA receptors (mGluRs & GABAbRs) improves temporal coding in the NM. However, the roles of neuromodulation in the NA remain unknown. In this thesis, we used in vitro whole-cell patch recordings from brain slices to address two basic questions. First, do mGluRs and GABAbRs regulate glutamatergic transmission in NA neurons? Second, if so, is the modulation cell type-specific? We found that activation of group II mGluRs, group III mGluRs, or GABAbRs suppressed glutamatergic transmission in NA neurons. Interestingly, the modulation is not cell-type specific, suggesting a universal modulatory role of these receptors in the sound intensity-coding pathway in the birds.
Yong Lu (Advisor)
Alexander Galazyuk (Committee Member)
Brett Schofield (Committee Member)
Neurosciences
Neuromodulation; Nucleus Augularis; G-protein-coupled receptors

Recommended Citations

Citations

  • Shi, W. (2011). Neuromodulation by G-protein-coupled receptors in the Avian Nucleus Angularis [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310504010

    APA Style (7th edition)

  • Shi, Wei. Neuromodulation by G-protein-coupled receptors in the Avian Nucleus Angularis. 2011. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1310504010.

    MLA Style (8th edition)

  • Shi, Wei. "Neuromodulation by G-protein-coupled receptors in the Avian Nucleus Angularis." Master's thesis, Kent State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=kent1310504010

    Chicago Manual of Style (17th edition)

kent1310504010
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© 2011, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.