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Epigenetic effects of adolescent nicotine exposure on rat serial pattern learning

Renaud, Samantha Marie
http://rave.ohiolink.edu/etdc/view?acc_num=kent1373722642

Abstract Details

2013, MA, Kent State University, College of Arts and Sciences / Department of Psychological Sciences.
Epigenetics is the study of changes in gene activity that do not involve alterations to the genetic code but still get passed down to at least one successive generation (Bird, 2007). This study investigated if adolescent nicotine exposure in one generation can impact the complex cognitive abilities of a subsequent generation. Rats in the F0 generation were given twice daily intraperitoneal injections of 1.0mg/kg nicotine or saline during adolescence. Once the animals reached adulthood, they were paired for breeding. 60 of their female offspring were used as the F1 generation and received the same drug exposure as the F0 generation. To evaluate complex cognitive abilities, the F1 generation rats were trained on a serial pattern learning (SPL) task for 49 days. SPL involves both stimulus-response learning and abstract rule learning making it an advantageous task when assessing more than one aspect of learning. Rats in the F1 generation were given either massed then spaced training or only spaced training. Acquisition of the various element types was then analyzed to assess the effects of F0 and F1 adolescent nicotine exposure as well as the spacing of training on adult offspring.
Stephen Fountain, Ph.D (Advisor)
57 p.
Behavioral Sciences; Neurosciences; Psychology
Adolescent Nicotine; Serial Pattern Learning; Epigenetics; Transgenerational; Animal Learning; Complex Cognition; Spacing Effect; Rat Weight; Chronic Nicotine Exposure; Adult Rat Cognition

Recommended Citations

Citations

  • Renaud, S. M. (2013). Epigenetic effects of adolescent nicotine exposure on rat serial pattern learning [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1373722642

    APA Style (7th edition)

  • Renaud, Samantha. Epigenetic effects of adolescent nicotine exposure on rat serial pattern learning. 2013. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1373722642.

    MLA Style (8th edition)

  • Renaud, Samantha. "Epigenetic effects of adolescent nicotine exposure on rat serial pattern learning." Master's thesis, Kent State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1373722642

    Chicago Manual of Style (17th edition)

kent1373722642
654
© 2013, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.