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Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex

Cooperrider, Jessica L
http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

Abstract Details

, MS, Kent State University, College of Arts and Sciences / School of Biomedical Sciences.
Stroke is currently the leading cause of disability in the United States. More effective forms of neurorehabilitation than are currently employed are thus necessary to further enhance recovery of function and reduce disability after injury. In this study, focal ischemia of the sensorimotor cortex was induced in a rat model after two weeks of pre-training on a skilled reaching task. Chronic deep brain stimulation (DBS) of the lateral cerebellar nucleus (LCN) at 30 Hz with concurrent upper limb training was then employed for five weeks post-stroke. Results indicate that the stimulated group attained functional recovery, with behavioral outcome scores at the conclusion of stimulation comparable to pre-stroke performance. Animals in the sham stimulation group did not achieve functional improvement through skilled reaching training alone. Active synapses in layers III/IV of the perilesional cortex were then counted. The DBS-treated animals demonstrated a two-fold increase in synaptic density at sites 100, 200, and 300 microns away from the lesion border, compared to sham animals. These results validate the effectiveness of 30 Hz chronic stimulation of the LCN for functional recovery from stroke and suggest that recovery may be mediated by synaptic plasticity or synaptogenesis of the remaining perilesional cortex.
Andre Machado (Advisor)
69 p.
Neurosciences
deep brain stimulation; stroke; neuromodulation

Recommended Citations

Citations

  • Cooperrider, J. L. (2013). Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

    APA Style (7th edition)

  • Cooperrider, Jessica. Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex. 2013. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388.

    MLA Style (8th edition)

  • Cooperrider, Jessica. "Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex." Master's thesis, Kent State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1374716388

    Chicago Manual of Style (17th edition)

kent1374716388
545
© 2013, some rights reserved.Creative Commons License Deep Brain Stimulation of the Lateral Cerebellar Nucleus of Rodents Following Ischemia Promotes Functional Recovery and Synaptic Plasticity in the Perilesional Cortex by Jessica L Cooperrider is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Kent State University and OhioLINK.