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MICRO AND NANOMATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATION_0406.pdf (7.61 MB)
ETD Abstract Container
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MICRO- AND NANO-MATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS
Author Info
Yan, Huan
ORCID® Identifier
http://orcid.org/0000-0002-3072-8276
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=kent1428155172
Abstract Details
Year and Degree
2015, PHD, Kent State University, College of Arts and Sciences / Chemical Physics.
Abstract
In my dissertation, three different types of micro- and nano-materials, including photoluminescent carbon nanodots, fluorescent magnetic nanoparticles and mesoporous silica microcapsules, are developed and studied for their use in drug delivery and bioimaging applications. First, a one-step solvent-free thermal treatment method to generate photoluminescent carbon nanodots is developed. The morphologies, chemical structures and fluorescent properties of the carbon nanodots generated from two different types of polymers (MPEG and PAA) are presented. These carbon nanodots can be used for bio-detecting and labelling. Second, a novel strategy that combines photoluminescent carbon nanodots with magnetic iron oxide nanoparticles is proposed. Monodisperse iron oxide nanoparticles are synthesized and the surface of the nanoparticles is modified with carbon nanodots originated from 3 different types of polymers (PF127, PVA and PAA). The functionalizability of the photoluminescent magnetic nanoparticles is demonstrated for bio-imaging and hyperthermia therapy applications. Finally, various types of monodispserse mesoporous silica microparticles are generated by glass-capillary microfluidic devices via double emulsion templates. These silica microcapsules can be used for drug delivery.
Committee
Chanjoong Kim (Advisor)
Hiroshi Yokoyama (Committee Member)
Qi-Huo Wei (Committee Member)
Min-Ho Kim (Committee Member)
Hanbin Mao (Committee Member)
Pages
149 p.
Subject Headings
Materials Science
;
Nanotechnology
Keywords
photoluminescent carbon nanodots
;
photoluminescent magnetic nanoparticles
;
drug delivery
;
silica microparticles
;
iron oxide nanoparticles
;
biomaterial
;
microfluidics
;
photostability
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Citations
Yan, H. (2015).
MICRO- AND NANO-MATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS
[Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1428155172
APA Style (7th edition)
Yan, Huan.
MICRO- AND NANO-MATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS.
2015. Kent State University, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=kent1428155172.
MLA Style (8th edition)
Yan, Huan. "MICRO- AND NANO-MATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS." Doctoral dissertation, Kent State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1428155172
Chicago Manual of Style (17th edition)
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Document number:
kent1428155172
Download Count:
1,235
Copyright Info
© 2015, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.