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A HISTOPATHOLOGICAL AND MAGNETIC RESONANCE IMAGING ASSESSMENT OF MYELOCORTICAL MULTIPLE SCLEROSIS: A NEW PATHOLOGICAL VARIANT

Vignos, Megan C
http://orcid.org/0000-0002-8329-7764
http://rave.ohiolink.edu/etdc/view?acc_num=kent1461528682

Abstract Details

2016, PHD, Kent State University, College of Arts and Sciences / School of Biomedical Sciences.
Multiple sclerosis (MS) is an inflammatory-mediated demyelinating, neurodegenerative disease characterized by a diverse clinical course and varying patterns of disease progression. It affects millions of individuals worldwide and is responsible for the majority of non-traumatic disability in young adults. Abnormal magnetic resonance imaging (MRI) signals in cerebral white matter (WM) are detected in MS patients, and these demyelinating white matter lesions (WML) are considered to be the pathological hallmark of MS, and are often observed macroscopically in postmortem brains. However, gray matter (GM) demyelination also occurs in MS brains and can exceed the amount of WM demyelination, but it can be detected only by immunohistochemical analysis. GM demyelination in the absence of WML has not yet been studied. The goal of this thesis was to determine the pathogenesis of cortical demyelination in MS patients with few cerebral WML (referred to as myelocortical MS) and the specificity of MRI in detecting the underlying MS WM pathology. Despite postmortem MRIs predictive of extensive cerebral WML burden, myelocortical MS patients had an unusually low number of macroscopic WML; however, significant cortical and spinal cord demyelination, axonal pathology in MRI WM abnormalities and significant brain atrophy. These data suggest that a substantial amount of cortical demyelination can occur independently of WML and that MRI is not specific for detection of MS cerebral WM demyelination. However, MRI is effective at detecting axonal swelling, edema and gliosis. Furthermore, this study supports the concept that MS may be a neurodegenerative disease with a secondary aberrant immune response.
Bruce Trapp, PhD (Advisor)
Jennifer McDonough, PhD (Committee Member)
Robert Dorman, PhD (Committee Member)
Mary Ann Raghanti, PhD (Committee Member)
Marilyn Norconk, PhD (Committee Member)
202 p.
Biomedical Research
Multiple Sclerosis, Histopathology, MRI, Neurodegeneration

Recommended Citations

Citations

  • Vignos, M. C. (2016). A HISTOPATHOLOGICAL AND MAGNETIC RESONANCE IMAGING ASSESSMENT OF MYELOCORTICAL MULTIPLE SCLEROSIS: A NEW PATHOLOGICAL VARIANT [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1461528682

    APA Style (7th edition)

  • Vignos, Megan. A HISTOPATHOLOGICAL AND MAGNETIC RESONANCE IMAGING ASSESSMENT OF MYELOCORTICAL MULTIPLE SCLEROSIS: A NEW PATHOLOGICAL VARIANT. 2016. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1461528682.

    MLA Style (8th edition)

  • Vignos, Megan. "A HISTOPATHOLOGICAL AND MAGNETIC RESONANCE IMAGING ASSESSMENT OF MYELOCORTICAL MULTIPLE SCLEROSIS: A NEW PATHOLOGICAL VARIANT." Doctoral dissertation, Kent State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1461528682

    Chicago Manual of Style (17th edition)

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© 2016, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.