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Habowski Dissertation (Aug 09).pdf (3.07 MB)

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Effects of the IL-6 Gene Polymorphism -174G/C on Interleukin-6 Production and Endurance Exercise Performance.

Habowski, Scott
http://rave.ohiolink.edu/etdc/view?acc_num=kent1532023529854917

Abstract Details

2018, PHD, Kent State University, College of Education, Health and Human Services / School of Health Sciences.
The purpose of the current study sought to determine the impact of the -174G/C polymorphism on the Interleukin-6 (IL-6) gene may have on IL-6 production and athletic performance. IL-6 has been seen to dramatically increase following endurance exercise events, with events of longer duration resulting in larger increases. This increase is thought to aide in metabolism which allows for sustained energy output during exercise. Alterations in the genetic sequence on the IL-6 gene at the -174 position within the promoter region have been recognized to result in significant differences in circulating IL-6 in various medical conditions. It is unknown if this change impacts IL-6 following exercise. Circulating IL-6 and endurance exercise performance were compared based on each participants sequence at the -174G/C polymorphism on the IL-6 gene. 19 trained participants completed a simulated sprint duathlon, all were instructed to complete the events as quickly as possible to mimic athletic competition as closely as possible. At pre-determined distances performance times and assessments of difficulty were recorded. IL-6 and circulating blood glucose were assessed prior to, during and following the simulated sprint duathlon. Analysis of variance was used to compare the recorded measurements based on participants genetic profile. Findings suggest that a particular genetic profile leads to significant differences in IL-6 production in the later stages of endurance exercise.
Derek Kingsley, Dr. (Committee Co-Chair)
130 p.
Sports Medicine

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Citations

  • Habowski, S. (2018). Effects of the IL-6 Gene Polymorphism -174G/C on Interleukin-6 Production and Endurance Exercise Performance. [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532023529854917

    APA Style (7th edition)

  • Habowski, Scott. Effects of the IL-6 Gene Polymorphism -174G/C on Interleukin-6 Production and Endurance Exercise Performance. . 2018. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1532023529854917.

    MLA Style (8th edition)

  • Habowski, Scott. "Effects of the IL-6 Gene Polymorphism -174G/C on Interleukin-6 Production and Endurance Exercise Performance. ." Doctoral dissertation, Kent State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532023529854917

    Chicago Manual of Style (17th edition)

kent1532023529854917
550
© 2018, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.