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Anterior cingulate cortex and ventral hippocampus inputs to the basolateral amygdala selectively control generalized fear

Ortiz, Samantha
http://rave.ohiolink.edu/etdc/view?acc_num=kent1540975191665517

Abstract Details

2018, MA, Kent State University, College of Arts and Sciences / Department of Psychological Sciences.
Nearly one third of Americans have been afflicted with an anxiety disorder. A common symptom of anxiety disorders is the over generalization of fear across a broad range of contextual cues. Anxiety disorders are associated with abnormalities of the anterior cingulate cortex (ACC) or hippocampus and hyperreactive amygdalae. We previously found that the ACC and ventral hippocampus (vHPC) underlie generalization of fear using a preclinical model. Here, we investigate the projections from the ACC and vHPC to the amygdala and their functions in generalized fear. A chemogenetic approach (DREADDs) was used to inhibit projections from the ACC or vHPC that terminate within the basolateral amygdala (BLA) at recent (1 day) or remote (28 days) time points after contextual fear conditioning (n = 224 male C57BL/6 mice; 64 F1 Hybrid of C57BL/6x129S1vmJ). Inactivating ACC or vHPC projections to the BLA significantly reduced generalization to the novel context but had no effect on fear in the training context. Our data indicate that the ACC supports generalization in a time-independent manner which is dependent on the training strength. We identified for the first time a strictly time-dependent role of the vHPC-BLA circuit in supporting remote generalized contextual fear. Dysfunctional signaling to the amygdala from the ACC or the hippocampus could underlie general fear responses associated with anxiety disorders. Our findings confirm that the ACC and vHPC regulate fear expressed in novel environments via projections to the BLA but do so as a result of training intensity or time respectively.
Aaron Jasnow, PhD (Advisor)
David Riccio, PhD (Committee Member)
Stephen Fountain, PhD (Committee Member)
Coifman Karin, PhD (Committee Member)
55 p.
Behavioral Psychology; Behavioral Sciences; Neurobiology; Neurosciences; Psychobiology

Recommended Citations

Citations

  • Ortiz, S. (2018). Anterior cingulate cortex and ventral hippocampus inputs to the basolateral amygdala selectively control generalized fear [Master's thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1540975191665517

    APA Style (7th edition)

  • Ortiz, Samantha. Anterior cingulate cortex and ventral hippocampus inputs to the basolateral amygdala selectively control generalized fear. 2018. Kent State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1540975191665517.

    MLA Style (8th edition)

  • Ortiz, Samantha. "Anterior cingulate cortex and ventral hippocampus inputs to the basolateral amygdala selectively control generalized fear." Master's thesis, Kent State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1540975191665517

    Chicago Manual of Style (17th edition)

kent1540975191665517
293
© 2018, some rights reserved.Creative Commons License Anterior cingulate cortex and ventral hippocampus inputs to the basolateral amygdala selectively control generalized fear by Samantha Ortiz is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Kent State University and OhioLINK.