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DFB DISSERTATION FINAL 4-14-20.pdf (2.17 MB)

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The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression

Barnard, David French
http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435

Abstract Details

2020, PHD, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
The dysregulation of pro-inflammatory cytokines as a result of stress exposure has become widely implicated in the complex etiology of depression. Patients with depression have been shown to have elevated levels of pro-inflammatory cytokines both in plasma and cerebral spinal fluid. During times of stress pro-inflammatory cytokines are primarily regulated by glucocorticoids and catecholamines that work in opposition to one another to inhibit (glucocorticoid receptor) or stimulate (beta-adrenergic receptor) pro-inflammatory cytokine production. While chronic stress can lead to heightened levels of both glucocorticoids and catecholamines, it is not known how the dysregulation of these systems affect the regulation of pro-inflammatory cytokines. This dissertation focused its work through three aims. Aim 1 explored norepinephrine’s regulation of microglial pro-inflammatory cytokines. Aim 2 examined sex differences in the regulation of brain IL-1 beta by glucocorticoids and catecholamines following chronic stress. Finally, aim 3 sought to uncover glucocorticoids effect on norepinephrine turnover. Together, these aims help to better understand how chronic stress alters the regulation of brain pro-inflammatory cytokines with implications for depression.
John Johnson (Advisor)
173 p.
Biology; Neurosciences
stress; depression; cytokines; norepinephrine; glucocorticoids

Recommended Citations

Citations

  • Barnard, D. F. (2020). The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435

    APA Style (7th edition)

  • Barnard, David. The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression. 2020. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435.

    MLA Style (8th edition)

  • Barnard, David. "The Regulation of Brain Pro-Inflammatory Cytokines: Implications for Stress and Depression." Doctoral dissertation, Kent State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=kent158687109882435

    Chicago Manual of Style (17th edition)

kent158687109882435
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This open access ETD is published by Kent State University and OhioLINK.