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A COMPARATIVE ANALYSIS OF MONOAMINE OXIDASE ENZYMES AND CANNABINOID RECEPTOR 1 AMONG PRIMATES

Jones, Danielle N
http://rave.ohiolink.edu/etdc/view?acc_num=kent1682504123739759

Abstract Details

2023, PHD, Kent State University, College of Arts and Sciences / School of Biomedical Sciences.
Monoamines include serotonin, dopamine, and norepinephrine. They play an important role in brain development, behavior, and cognition, and their dysregulation has been implicated in a wide range of psychiatric and neurological disorders. The degradation of all monoamines is mediated, in part, by monoamine oxidase-A and -B, which are mitochondrial outer membrane enzymes that are key to maintaining monoamine availability. Because monoamines contribute to the modulation of social awareness, aggression, and affiliative behaviors, it is important we understand how they contribute to primate behavioral diversity, especially human-unique features that may have implications for neurological disorders. One component of the present research focused on monoamine oxidase enzymes from a comparative perspective to better understand their role in the pathophysiology of disease and primate social style. The cannabinoid system is ubiquitous throughout the body and has a wide range of functions, however, in the brain, it is a widely distributed neuromodulatory system. Cannabinoids are lipids that are either produced endogenously, like 2-archeadonylglycerol and anandamide, or come from exogenous plant or synthetic sources. While several receptors are activated by cannabinoids, the two most well studied are cannabinoid receptor 1 and 2 (CB1R and CB2R), which are both G-protein coupled receptors. In the brain, CB1R modulates circuitry related to anxiety, impulsivity, aggression, reward, and stress, while CB2R is more involved in immune signaling. Comparative research on the cannabinoid system is intriguing given that distribution differences between rats and humans have been observed, in addition to functional differences among rodent species. However, compared to rodents, little is known about how the cannabinoid system compares across primate species. The current lack of comparative studies among nonhuman primates restricts our ability to understand the cannabinoid system from an evolutionary perspective. Knowledge of this system’s density, distribution, and characteristics is useful for understanding the neural mechanisms that underlie features of brain function, behavior, and diseases that may be unique to humans. The present research aimed to address this knowledge gap by characterizing CB1R’s expression in the basolateral amygdala of nine primate species, including humans, to clarify the role of the cannabinoid system in primate social diversity and brain evolution.
Mary Ann Raghanti (Advisor)
Anthony Tosi (Committee Member)
John Johnson (Committee Chair)
Wilson Chung (Committee Member)
136 p.
Neurobiology
Serotonin; Dopamine; Cannabinoid; Amygdala; Primate brain evolution

Recommended Citations

Citations

  • Jones, D. N. (2023). A COMPARATIVE ANALYSIS OF MONOAMINE OXIDASE ENZYMES AND CANNABINOID RECEPTOR 1 AMONG PRIMATES [Doctoral dissertation, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=kent1682504123739759

    APA Style (7th edition)

  • Jones, Danielle. A COMPARATIVE ANALYSIS OF MONOAMINE OXIDASE ENZYMES AND CANNABINOID RECEPTOR 1 AMONG PRIMATES. 2023. Kent State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=kent1682504123739759.

    MLA Style (8th edition)

  • Jones, Danielle. "A COMPARATIVE ANALYSIS OF MONOAMINE OXIDASE ENZYMES AND CANNABINOID RECEPTOR 1 AMONG PRIMATES." Doctoral dissertation, Kent State University, 2023. http://rave.ohiolink.edu/etdc/view?acc_num=kent1682504123739759

    Chicago Manual of Style (17th edition)

kent1682504123739759
101
© 2023, all rights reserved.
This open access ETD is published by Kent State University and OhioLINK.