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THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION

Mesfin, Fikir
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335958470

Abstract Details

2012, BS, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
Circadian rhythm is one of the most fundamental regulators of physiology and behavior. The transcription-translation feed-back loop of clock genes control metabolic activity by regulating the transcription of key proteins and enzymes. The transcription proteins BMAL1 and CLOCK are two of the proteins that are involved in translation-transcription feed-back loop. They dimerize and bind to promoter regions and positively regulate the expression of other clock genes. The expressed clock proteins in turn can negatively regulate the action of CLOCK and BMAL1 and/or regulate the expression of other metabolic proteins. Because BMAL1 is an integral part of the circadian rhythm and its roles in whole-body metabolism, the modification of its expression can disrupt muscle metabolism. The overexpression of BMAL1 in skeletal muscles may have a broader impact on whole-body metabolic regulation.
Colleen Novak, PhD (Advisor)
Paul Sampson, PhD (Committee Member)
Eric Mintz, PhD (Committee Member)
Roger Gregory, PhD (Committee Member)
64 p.
Biology
Circadian rhythm; SCN; CLOCK; BMAL1; skeletal muscle

Recommended Citations

Citations

  • Mesfin, F. (2012). THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335958470

    APA Style (7th edition)

  • Mesfin, Fikir. THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION. 2012. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335958470.

    MLA Style (8th edition)

  • Mesfin, Fikir. "THE INFLUENCE OF MODIFICATION OF BMAL1 EXPRESSION IN SKELETAL MUSCLE ON WHOLE-BODY METABOLISM AND FUNCTION." Undergraduate thesis, Kent State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335958470

    Chicago Manual of Style (17th edition)

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© 2012, all rights reserved.
This open access ETD is published by Kent State University Honors College and OhioLINK.