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The Effects of Cannabinoids on Regeneration Rates and Potential Matrix Metalloproteinase and Collagenase Levels in Planaria (Dugesia tigrina)

Blasiman, Julia L
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1387197523

Abstract Details

2013, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Planaria are free-living flatworms that are well known for their regenerative abilities, though the exact mechanisms for this process remain unknown. Several studies have shown that cannabinoids have the potential to alter the behavior of Planaria. These two pieces of information raise the question of whether or not cannabinoid agonists and antagonists also have the potential to affect the rate at which Planaria regenerate as well as affect the levels of potential collagenases and matrix metalloproteinases (MMPs) that may be critical to tissue remodeling. In regard to regeneration rates, it was found that cannabinoid agonist Arachidonyl-2'-chloroethylamide (ACEA) and cannabinoid antagonist Rimonabant did not affect regeneration rates or enzyme levels at the 1µM concentration level to a statistically significant degree. There was a significant amount of variation between individual organisms. Therefore, further experimentation with a clonal strain of Planaria along with higher dosages of the test chemicals may help clarify the effects cannabinoids have on planarian regeneration and enzyme levels, which will help provide new insight on the potential mechanisms behind planarian regeneration.
Robert Hamilton, IV (Advisor)
Paul Bagavandoss (Committee Member)
Leslie Heaphy (Committee Member)
Christine Kauth (Committee Member)
35 p.
Biology; Cellular Biology; Organismal Biology; Zoology
Dugesia tigrina, Planaria, regeneration, cannabinoid, ACEA, Rimonabant, matrix metalloproteinase, collagenase

Recommended Citations

Citations

  • Blasiman, J. L. (2013). The Effects of Cannabinoids on Regeneration Rates and Potential Matrix Metalloproteinase and Collagenase Levels in Planaria (Dugesia tigrina) [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1387197523

    APA Style (7th edition)

  • Blasiman, Julia. The Effects of Cannabinoids on Regeneration Rates and Potential Matrix Metalloproteinase and Collagenase Levels in Planaria (Dugesia tigrina). 2013. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1387197523.

    MLA Style (8th edition)

  • Blasiman, Julia. "The Effects of Cannabinoids on Regeneration Rates and Potential Matrix Metalloproteinase and Collagenase Levels in Planaria (Dugesia tigrina)." Undergraduate thesis, Kent State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1387197523

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Kent State University Honors College and OhioLINK.