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Jeremy Shaw's Senior Honors Thesis.pdf (1.84 MB)

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The Implications Of Gap Junction Inhibition In Jurkat Cell-Cell Communication And Proliferation

Shaw, Jeremy Joseph Porter
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1398988837

Abstract Details

2014, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Acute myeloid leukemia (AML) is the most common adult hematologic malignancy, characterized by the rapid proliferation and self-renewal of abnormal leukocytes with subsequent interference of normal hematopoiesis. Due to their close confines in bone marrow, the communication between leukemic cells as well as their surrounding stroma is likely to support their survival and protection from apoptosis. However, the mechanisms behind direct cell-cell communication in leukemia are largely undefined. Gap junctions (GJs) are specialized intercellular connections, composed of connexin proteins, allowing for direct exchange between cytoplasm of adjacent cells enabling them to respond in a coordinated fashion. There has been no description of communication directly between leukemic cells and the effects it may have on tumor growth and resistance. In order to determine whether homotypic communication is occurring in AML, we used in vitro models to interrogate GJ-mediated communication through the use of two clinically relevant GJ inhibitors, Carbenoxolone and 1-Octanol.
Douglas Kline, Dr. (Advisor)
Justin Lathia, Dr. (Advisor)
Chris Malcuit, Dr. (Committee Member)
Paul Sampson, Dr. (Committee Member)
Jon Secaur, Dr. (Committee Member)
29 p.
Biomedical Research
Acute Myeloid Leukemia; Jurkat Cells; Gap Junctions; 1-Octanol; Carbenoxolone; Calcein AM; DiI;

Recommended Citations

Citations

  • Shaw, J. J. P. (2014). The Implications Of Gap Junction Inhibition In Jurkat Cell-Cell Communication And Proliferation [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1398988837

    APA Style (7th edition)

  • Shaw, Jeremy. The Implications Of Gap Junction Inhibition In Jurkat Cell-Cell Communication And Proliferation. 2014. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1398988837.

    MLA Style (8th edition)

  • Shaw, Jeremy. "The Implications Of Gap Junction Inhibition In Jurkat Cell-Cell Communication And Proliferation." Undergraduate thesis, Kent State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1398988837

    Chicago Manual of Style (17th edition)

ksuhonors1398988837
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© 2014, all rights reserved.
This open access ETD is published by Kent State University Honors College and OhioLINK.