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Nolan Brown Thesis.pdf (1.84 MB)

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Localization of hemoglobin in MS cortex and its relevance to MS neuropathology

Brown, Nolan J
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834

Abstract Details

2014, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and progressive disability. Previous research has shown that the hemoglobin beta subunit (Hbb) is present in greater quantities in mitochondrial fractions of MS brains compared to non-diseased brains. Characterizing the presence of the Hbb in MS brains can help elucidate the causes and pathology of MS. This thesis aims to determine whether the presence of Hbb is preferentially increased in specific neuron types or in particular regions of the brain using immunohistochemistry and in situ hybridization techniques. Hbb protein has been successfully co-localized with neurofilament, tyrosine hydroxylase, and CD68 in post-mortem MS brain samples, and research is currently ongoing to co-localize Hbb mRNA with neurofilament and Hbb proteins.
Jennifer McDonough, Ph. D. (Advisor)
46 p.
Biology; Neurobiology
Multiple sclerosis; hemoglobin; neuron; disease; degenerative

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Citations

  • Brown, N. J. (2014). Localization of hemoglobin in MS cortex and its relevance to MS neuropathology [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834

    APA Style (7th edition)

  • Brown, Nolan. Localization of hemoglobin in MS cortex and its relevance to MS neuropathology. 2014. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834.

    MLA Style (8th edition)

  • Brown, Nolan. "Localization of hemoglobin in MS cortex and its relevance to MS neuropathology." Undergraduate thesis, Kent State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1399400834

    Chicago Manual of Style (17th edition)

ksuhonors1399400834
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© 2014, some rights reserved.Creative Commons License Localization of hemoglobin in MS cortex and its relevance to MS neuropathology by Nolan J Brown is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by Kent State University Honors College and OhioLINK.