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THE FORMATION OF NANO-SIZED CHEMICAL DOMAINS AND THE SUBSEQUENT EFFECTS ON CONNECTIVE TISSUE ADHESION

Abstract Details

2014, BS, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
Biomaterials must adequately facilitate tissue fixation while maintaining mechanical properties. Surface rigidity and roughness have been shown to modulate soft tissue response. In order to improve soft tissue adhesion on rigid substrates, phase separation of organosilanes was employed to create self-assembled monolayers (SAMs) of tunable wettability by creating nano-size hydrophobic and hydrophilic domains capable of eliciting phenotypic response in skeletal myoblast cells. P-aminophenyltrimethoxysilane (APhMS) and octadecyltrichlorosilane (OTS) was varied in a binary solution in order to achieve SAMs with nanoislands. C2C12 skeletal myoblast cells were seeded onto prepared SAMs in order to investigate changes in cell behavior due to surface interactions. Hydrophilic SAMs were observed to enhance cell spreading, viability, and myotube formation on glass surfaces. Furthermore, 5:5 APhMS: OTS was found to increase myoblast differentiation and anisotropy through cell mechanosensing of nanoislands. Virtual roughness of 5:5 APhMS:OTS was created by nanosized methyl-terminated pillars in an amine-terminated matrix.
Christopher Malcuit, Ph.D. (Advisor)
Grant McGimpsey, Ph.D. (Committee Member)
Edgar Kooijman, Ph.D. (Committee Member)
Paul Sampson, Ph.D. (Committee Member)
48 p.

Recommended Citations

Citations

  • Strang, W. C. (2014). THE FORMATION OF NANO-SIZED CHEMICAL DOMAINS AND THE SUBSEQUENT EFFECTS ON CONNECTIVE TISSUE ADHESION [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1418413006

    APA Style (7th edition)

  • Strang, William. THE FORMATION OF NANO-SIZED CHEMICAL DOMAINS AND THE SUBSEQUENT EFFECTS ON CONNECTIVE TISSUE ADHESION. 2014. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1418413006.

    MLA Style (8th edition)

  • Strang, William. "THE FORMATION OF NANO-SIZED CHEMICAL DOMAINS AND THE SUBSEQUENT EFFECTS ON CONNECTIVE TISSUE ADHESION." Undergraduate thesis, Kent State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1418413006

    Chicago Manual of Style (17th edition)