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Assessment of Cognitive Deficits and Sex Differences in Adult Rats after Adolescent Methylphenidate Exposure

Thalluri, Rajaa
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1462516537

Abstract Details

2016, BS, Kent State University, College of Arts and Sciences / Department of Psychological Sciences.
Methylphenidate (MPD), commonly known as Ritalin, is widely used in treating Attention Deficit Hyperactivity Disorder (ADHD), which is one of the most common childhood psychiatric disorders (Storebo et al., 2015). Serial pattern learning is a behavioral task that depends on multiple learning and cognitive systems. Rowan et al. (2015) found in a previous study with male rats that adolescent exposure to MPD caused cognitive impairments in serial pattern learning in adulthood long after MPD exposure ended. However, no study has yet examined sex differences in the effects of early exposure to MPD on adult cognitive capacity. In this study, 12 male and 12 female rats received the same exposures via intraperitoneal injections as in the Rowan et al. (2015) study, namely, 20.0 mg/kg/day MPD, and an equal number of male and female control rats received saline vehicle for 5 days/week for 7 weeks. MPD-exposed and control rats learned to perform the same 24-element serial pattern used by Rowan et al. (2015), but the rats differed in that they were from different breeding stock and they experienced twice as many serial patterns per day in training. A significant sex difference was observed for one measure of serial pattern learning. However, we did not observe any effects of adolescent MPD for either sex in this paradigm. Our results suggest that differences in training procedures may affect the ability to measure adolescent MPD-induced impairments of adult cognition.
Stephen Fountain, Ph.D. (Advisor)
David Riccio, Ph.D. (Committee Member)
Paul Sampson, Ph.D. (Committee Member)
Jesse Young, Ph.D. (Committee Member)
33 p.
Behavioral Psychology; Cognitive Psychology; Neurosciences; Psychology
Adolescent Methylphenidate; Adult Rat Cognition; Animal Learning; Complex Cognition; Serial Pattern Learning; Animal Cognition; Psychology; Neuroscience; Behavioral Psychology;

Recommended Citations

Citations

  • Thalluri, R. (2016). Assessment of Cognitive Deficits and Sex Differences in Adult Rats after Adolescent Methylphenidate Exposure [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1462516537

    APA Style (7th edition)

  • Thalluri, Rajaa. Assessment of Cognitive Deficits and Sex Differences in Adult Rats after Adolescent Methylphenidate Exposure. 2016. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1462516537.

    MLA Style (8th edition)

  • Thalluri, Rajaa. "Assessment of Cognitive Deficits and Sex Differences in Adult Rats after Adolescent Methylphenidate Exposure." Undergraduate thesis, Kent State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1462516537

    Chicago Manual of Style (17th edition)

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This open access ETD is published by Kent State University Honors College and OhioLINK.