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Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor

Campbell, Mark Wesley
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1494608472107543

Abstract Details

2017, BS, Kent State University, College of Arts and Sciences / Department of Chemistry and Biochemistry.
Nitroxyl (HNO) is a biologically relevant small molecule with considerable clinical promise for the treatment of heart failure. However, studies of the chemistry and biology of nitroxyl are hampered by its instability in aqueous solution. To aid in biological and chemical studies, nitroxyl donors (molecules that degrade to release HNO) have been synthesized which utilize a 3-hydroxy-2-naphthyl methyl (HNM) OH protecting group. Our group’s focus is on the synthesis of nitroxyl donors that rapidly release HNO under physiological conditions through photoactivation. First generation HNO donors released HNO upon photoactivation, but competition was also observed from a redox side reaction. In this study, we are probing the impact of a methyl substituent at the benzylic position on these competing processes. The synthesis and photochemical anaylsis of such a donor are herein described.
Paul Sampson, Ph. D. (Advisor)
Alexander Seed, Ph. D. (Advisor)
Margaret Leslie, Ph. D. (Committee Member)
Douglas Kline, Ph. D. (Committee Member)
176 p.
Chemistry
Organic Synthesis Nitroxyl HNO photochemistry

Recommended Citations

Citations

  • Campbell, M. W. (2017). Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1494608472107543

    APA Style (7th edition)

  • Campbell, Mark. Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor. 2017. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1494608472107543.

    MLA Style (8th edition)

  • Campbell, Mark. "Synthetic Explorations in the Pursuit of a Rapid, Photoactivatable, Nitroxyl Donor." Undergraduate thesis, Kent State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1494608472107543

    Chicago Manual of Style (17th edition)

ksuhonors1494608472107543
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© 2017, all rights reserved.
This open access ETD is published by Kent State University Honors College and OhioLINK.