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Full text of this paper is not available in the ETD Center. Copies may be available for inter-library loan from Kent State University or may be available for purchase from Proquest/UMI

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Evaluation of Anti-Epileptic Effects of Human Chorionic Gonadotrophin: Potential Relevance to Alzheimer's Disease

Van Coppenolle, Jenna Denyse
http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1607943688194936

Abstract Details

2020, BS, Kent State University, College of Arts and Sciences / Department of Biological Sciences.
To date, the study of hormones in relation to both AD and epilepsy have primarily focused on the involvement of gonadal steroids. However, recent work from our laboratory and others have identified a role for the LH receptor in the brain. In particular, its ability to regulate synaptic structure, known to be highly sensitive to activity, and cognitive function. Recent reports also show the ability of hCG, a LH receptor analog, to regulate excitatory and inhibitory function in vitro. Therefore, given the multiple overlapping links between these two disorders, the potential ability of LH receptor activation to modulate neuronal activity, and the increased incidence of seizure activity in AD APP/PS1 model females, here we address whether LHCGR is involved in seizure regulation in APP/PS1 animals and in wild-types model of epilepsy. We are also exploring potential genes that predispose the APP/PS1 females to increased seizure activity in relation to males and time, through an exhaustive review of RNAseq data. We have found that hCG treatment reduces the mortality of APP/PS1 females however does not alter seizure-related parameters on the Racine scale upon injection with kainic acid. We have also identified four potential genes of interest for future explorations of seizures in APP/PS1 females.
Gemma Casadesus-Smith (Advisor)
Helen Piontkivska (Advisor)
Lee Gilman (Committee Member)
Elda Hegmann (Committee Member)
64 p.
Biology; Neurosciences
Epilepsy; Alzheimers; LH; Hormones; hCG; excitotoxicity; seizures; APPPS1

Recommended Citations

Citations

  • Van Coppenolle, J. D. (2020). Evaluation of Anti-Epileptic Effects of Human Chorionic Gonadotrophin: Potential Relevance to Alzheimer's Disease [Undergraduate thesis, Kent State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1607943688194936

    APA Style (7th edition)

  • Van Coppenolle, Jenna. Evaluation of Anti-Epileptic Effects of Human Chorionic Gonadotrophin: Potential Relevance to Alzheimer's Disease . 2020. Kent State University, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1607943688194936.

    MLA Style (8th edition)

  • Van Coppenolle, Jenna. "Evaluation of Anti-Epileptic Effects of Human Chorionic Gonadotrophin: Potential Relevance to Alzheimer's Disease ." Undergraduate thesis, Kent State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1607943688194936

    Chicago Manual of Style (17th edition)

ksuhonors1607943688194936