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ANALYSIS OF APOPTOTIC SIGNNALING PATHWAYS INDUCED BY NITROPARABENS IN MELANOMA CELLS

Hildebrandt, Isabella
http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566915

Abstract Details

2016, Bachelor of Science, Marietta College, Chemistry.
Novel nitroparabens, mononitroparaben and dinitroparaben, were investigated for potential to replace the most commonly used paraben, methylparaben, which is shown to be toxic at the 5mM level. Human melanoma M624 cells were treated with 2.5mM, 5mM, and 10mM mononitroparaben and 2.5mM and 5mM dinitroparaben in the presence and absence of 25 mJ/cm2 ultraviolet B light. Apoptosis was analyzed through PARP protein analysis via western blot. Minimum inhibitory concentrations were determined for the nitroparabens and methylparaben on Escherichia coli, Proteus vulgaris, Staphylococcus aureus, and Enterococcus faecalis. Mononitroparaben was the best antimicrobial agent with the greatest MIC being at 0.8mM. Mononitroparaben induced apoptosis at 10mM, while dinitroparaben induced apoptosis at 5mM. Nitroparabens have shown to induce apoptosis when exposed to UV-B irradiation at all concentrations. Mononitroparaben would need to be tested on normal human keratinocytes and the 0.8mM level to determine whether it could be a viable substitute for methylparaben on the commercial market.
Suzanne Goerge-Parsons, Dr. (Advisor)
37 p.
Biochemistry; Chemistry
nitroparaben; parabens; methylparaben; melanoma; ultraviolet; apoptosis

Recommended Citations

Citations

  • Hildebrandt, I. (2016). ANALYSIS OF APOPTOTIC SIGNNALING PATHWAYS INDUCED BY NITROPARABENS IN MELANOMA CELLS [Undergraduate thesis, Marietta College]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566915

    APA Style (7th edition)

  • Hildebrandt, Isabella. ANALYSIS OF APOPTOTIC SIGNNALING PATHWAYS INDUCED BY NITROPARABENS IN MELANOMA CELLS . 2016. Marietta College, Undergraduate thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566915.

    MLA Style (8th edition)

  • Hildebrandt, Isabella. "ANALYSIS OF APOPTOTIC SIGNNALING PATHWAYS INDUCED BY NITROPARABENS IN MELANOMA CELLS ." Undergraduate thesis, Marietta College, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1463566915

    Chicago Manual of Style (17th edition)

marhonors1463566915
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© 2016, all rights reserved.
This open access ETD is published by Marietta College Honors Theses and OhioLINK.