Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


mco1177608338.pdf (1.94 MB)

ETD Abstract Container

Abstract Header

The Heat Shock Protein 70 Response to Acute and Endurance Exercise

Brickman, Todd
http://rave.ohiolink.edu/etdc/view?acc_num=mco1177608338

Abstract Details

2007, Doctor of Philosophy in Medical Sciences (Ph.D.), University of Toledo, College of Graduate Studies.
Acute and endurance exercise has previously been shown to induce a stress response. The aim of this project was to investigate the HSP70 response to acute and chronic exercise, among several inbred strains of rats, and selectively bred rats. Peripheral skeletal muscles dramatically increased (p<0.05) their HSP synthesis after an acute high intensity bout of exercise for only the untrained runners. However, increased training intensity was relatively proportional to increased HSP70’s inducible isoform (HSP70i) content, demonstrating that trained animals adapt to the stress of prolonged training stress by increasing their HSP70i content levels. Rats artificially selected for low (LCR) or high (HCR) intrinsic aerobic capacity demonstrated no significant changes in HSP70i content for any tissues in either the founder population (G0) or the third generation (G3). However, at generation 10 (G10), there was a significant difference between sedentary LCR and HCR rats HSP70i content (p<0.05) as well as a significant increase from the sedentary G0 rats to sedentary G10 HCR. Furthermore, artificial selection has displayed a separation in aerobic endurance performance correlated with an equivalent segregation of HSP70i content in sedentary rats. Among three different rat strains with differing aerobic exercise capabilities, their final exercise performance correlated with HSP70i content while their sedentary levels did not. Data from these studies support HSP70i as having an influencing role in aerobic exercise performance and provides evidence that one set of genes may dictate the initial exercise performance level and another set of genes the response to training.
Edwin Sanchez (Advisor)
175 p.
Health Sciences, Pharmacology
HSP 70; Exercise; Stress Protein; Genetic Models; Aerobic Capacity; Training

Recommended Citations

Citations

  • Brickman, T. (2007). The Heat Shock Protein 70 Response to Acute and Endurance Exercise [Doctoral dissertation, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1177608338

    APA Style (7th edition)

  • Brickman, Todd. The Heat Shock Protein 70 Response to Acute and Endurance Exercise. 2007. University of Toledo, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1177608338.

    MLA Style (8th edition)

  • Brickman, Todd. "The Heat Shock Protein 70 Response to Acute and Endurance Exercise." Doctoral dissertation, University of Toledo, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1177608338

    Chicago Manual of Style (17th edition)

mco1177608338
745
© 2007, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.