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Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains

Ghosh, Sumona
http://rave.ohiolink.edu/etdc/view?acc_num=mco1182807006

Abstract Details

2007, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Graduate Studies.
To determine the effect of genetic factors on training-induced change in glucose tolerance, Copenhagen (COP) and DA rats were studied. After 4 weeks of endurance swim training, an improvement in glucose tolerance was assessed by performing glucose tolerance tests on trained and untrained rats. Intermediate metabolites in tissues and blood were also investigated. DA showed a greater improvement (P<0.05) in glucose tolerance than did COP in response to training. There were no differences in adaptive changes in plasma insulin and C-peptide, muscle oxidative capacity, lipogenic capacity in the liver, blood lipids, or muscle TG between the two strains in response to training. Among variables (hepatic glycogen, triglyceride, and CEACAM1 expression) that showed difference between the two strains, increased hepatic CEACAM1 expression in DA coincided with a large improvement in training-induced glucose tolerance in DA rats, implicating it as the most influential factor on the strain difference seen in glucose tolerance.
Abraham Lee (Advisor)
74 p.
Biology, General
Exercise training; glucose tolerance; CEACAM1; metabolic intermediates; inbred rat strains

Recommended Citations

Citations

  • Ghosh, S. (2007). Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1182807006

    APA Style (7th edition)

  • Ghosh, Sumona. Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains. 2007. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1182807006.

    MLA Style (8th edition)

  • Ghosh, Sumona. "Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains." Master's thesis, University of Toledo, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1182807006

    Chicago Manual of Style (17th edition)

mco1182807006
514
© 2007, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.