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MBG - Induced EMT

Nadour, Alaa M
http://rave.ohiolink.edu/etdc/view?acc_num=mco1194969320

Abstract Details

2007, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Graduate Studies.
Interest and research in Epithelial-mesenchymal transition are currently growing at a high level due the importance of this process in embryogenesis, organ development, tumor progression, and several pathologic conditions in adult tissues. Epithelial to mesenchymal transformation (EMT) is now believed to play a major role in the pathogenesis of renal interstitial fibrosis, and organ fibrosis in general. This unique event along with other several cellular pathways, leads to excessive accumulation and deposition of extracelular matrix components that cause fibrous scars and destruction of kidney parenchyma, with consequent end-stage renal failure.Multiple intracellular signaling pathways are implicated in the regulation of this complicated event. Marinobufagenin (MBG), a cardiotonic steroid, and an inhibitor of the enzymatic activity of Na/K-ATPase, has shown a potency to activate multiple signaling pathways that ultimately leads to EMT in renal epithelial cells. Therefore, it was reasonable to hypothesize that elevated levels of this cardiotonic steroid could be a potent inducer of EMT. Our study on the porcine proximal epithelial cell line demonstrates that Marinobufagenin induces EMT in time and concentration dependent fashion.
Joseph Shapiro (Advisor)
34 p.
Biology, Molecular
MBG; EMT; TGF-¿¿¿¿; Epithelial; Mesenchymal; cells; LEF-1

Recommended Citations

Citations

  • Nadour, A. M. (2007). MBG - Induced EMT [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1194969320

    APA Style (7th edition)

  • Nadour, Alaa. MBG - Induced EMT. 2007. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1194969320.

    MLA Style (8th edition)

  • Nadour, Alaa. "MBG - Induced EMT." Master's thesis, University of Toledo, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1194969320

    Chicago Manual of Style (17th edition)

mco1194969320
568
© 2007, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.