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Are Mitochondria a Potential Target for Anti-Cancer Therapy in Carcinoid Tumors?

Zahedi, Shadi
http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079

Abstract Details

2010, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Medicine.
Gastrointestinal (GI) carcinoids are slow growing malignancies of neuroendocrine phenotype that can behave aggressively. To date, there are no effective therapies for metastatic carcinoid cancer. Previous work by our lab and others has shown that carcinoids express variety of voltage-operated (VOCCs) and non-voltage-operated Ca2+ channels to allow Ca2+ to enter the cell. Although, the role of Ca2+ entry in these tumors is not well understood, previous work by our group and others has shown that mitochondria are important regulators of voltage-operated and non-voltage-operated Ca2+ entry. In addition, cancer cells typically exhibit mitochondrial dysfunction and poor anti-oxidant status. These observations and the central role that mitochondria play in metabolism, Ca2+ homeostasis and cell death pathways make mitochondria an appealing potential target for anti-cancer treatment in carcinoid tumors. We used an spectrum of human cancer cell lines and a variety of microfluorescence methods including wide-field, confocal, and total internal reflection (TIRF) microscopy to assess Ca2+ signaling and mitochondrial function in combination with pharmacological interventions to assay whether mitochondria are a potential target for anti-cancer therapy. To this end, we tested the effectiveness of an oxidant therapy approach in carcinoid cells.
David Giovannucci, Ph.D. (Committee Chair)
Andrew Beavis, Ph.D. (Committee Member)
Vazquez Guillermo, Ph.D. (Committee Member)
79 p.
Biomedical Research; Molecular Biology; Scientific Imaging
carcinoid tumors; mitochondrial; calcium signaling; TIRF microscopy; oxidant therapy; vitamin K3; vitamin C

Recommended Citations

Citations

  • Zahedi, S. (2010). Are Mitochondria a Potential Target for Anti-Cancer Therapy in Carcinoid Tumors? [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079

    APA Style (7th edition)

  • Zahedi, Shadi. Are Mitochondria a Potential Target for Anti-Cancer Therapy in Carcinoid Tumors? 2010. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079.

    MLA Style (8th edition)

  • Zahedi, Shadi. "Are Mitochondria a Potential Target for Anti-Cancer Therapy in Carcinoid Tumors?" Master's thesis, University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1280427079

    Chicago Manual of Style (17th edition)

mco1280427079
1,082
© 2010, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.