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Feasibility Study of Intensity Modulation for Low Dose Rate External Beam Radiation Therapy

Gordon, Ian R.
http://rave.ohiolink.edu/etdc/view?acc_num=mco1290109815

Abstract Details

2010, Master of Science in Biomedical Sciences (MSBS), University of Toledo, College of Medicine.
Previous studies have shown that low dose rate radiation therapy has radiobiological advantages for normal tissue. External irradiation techniques have been developed which use static blocked fields to irradiate a target which give a uniform dose rate over the area of the field but are unable to preferentially reduce dose to critical structures near the target. Intensity modulated radiation therapy techniques allow for the reduction in dose to critical structures but the standard technique of IMRT using a multi-leaf collimator has the disadvantage of not delivering a continuous dose rate across the area of the field being irradiated. Using compensator based IMRT compounds the benefits of IMRT with the benefits of low dose rate delivery and gives the patient a better treatment option than just one or the other individually. Because of the greater demands of IMRT on the linear accelerator a study of performance in the low dose rate ranges was carried out to determine if the accelerator was accurate enough to deliver this treatment with a non-standard range of machine parameters. The study entailed using a variety of dosimetry equipment to measure the basic beam parameter accuracy of the low dose rate techniques as compared to normal dose rate techniques and to ensure an accurate delivery of a low dose rate IMRT treatment. The outcome of this study showed that the machine does produce an accurate and dependable beam which allowed the measurement of a compensator based IMRT plan to be delivered as accurately as normal dose rate techniques.
E. Ishmael Parsai, PhD (Advisor)
Michael Dennis, PhD (Committee Member)
David Pearson, PhD (Committee Member)
Diana Shvydka, PhD (Committee Member)
54 p.
Radiation
LDREBRT

Recommended Citations

Citations

  • Gordon, I. R. (2010). Feasibility Study of Intensity Modulation for Low Dose Rate External Beam Radiation Therapy [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1290109815

    APA Style (7th edition)

  • Gordon, Ian. Feasibility Study of Intensity Modulation for Low Dose Rate External Beam Radiation Therapy. 2010. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1290109815.

    MLA Style (8th edition)

  • Gordon, Ian. "Feasibility Study of Intensity Modulation for Low Dose Rate External Beam Radiation Therapy." Master's thesis, University of Toledo, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1290109815

    Chicago Manual of Style (17th edition)

mco1290109815
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© 2010, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.