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The Preparation and Characterization of Poloxamer-based Temperature-sensitive Hydrogels for Topical Drug Delivery.

Gandra, Sarath Chandra Reddy
http://rave.ohiolink.edu/etdc/view?acc_num=mco1373375178

Abstract Details

2013, Master of Science in Pharmaceutical Science (MSP), University of Toledo, College of Pharmacy.
Stimuli-sensitive hydrogels change their swelling behavior and drug release by sensing changes in the surrounding environment. One example is temperature-sensitive hydrogels which change their swelling behavior in response to a change in the environmental temperature. Poloxamers are tri-block copolymers that exhibit thermoreversible properties by transforming from a liquid-like behavior to gel-like behavior above a certain temperature called sol-gel transition temperature. By varying the concentration of poloxamer and other excipients, hydrogels with sol-gel transition point close to body temperature can be achieved. The aim of the present study was to develop poloxamer hydrogels as in situ gelling formulation for topical drug delivery.. The anti-fungal drug fluconazole (FLZ) was used as a model drug substance. First, pre-formulation work on the solubility of FLZ in different co-solvents was performed. Then, eight different formulations containing 1% FLZ in poloxamer and a particular co-solvent (propylene glycol or Transcutol®-P) of various concentrations were prepared. The formulations were characterized for transition temperatures, rheological, mechanical, and mucoadhesive properties. Fluconazole permeability and antifungal effect of the systems were evaluated. Except for one formulation, all hydrogels exhibited thermosensitive property, i.e. changing from Newtonian (liquid-like) behavior at 20°C to non-Newtonian (gel-like) behavior at 37°C. Transcutol®-P increased the transition temperature of the formulations, while the opposite effect was observed for propylene glycol. At body temperature, formulations with high poloxamer concentrations (17%) rendered gels with higher values in viscosity, compressibility and hardness. Formulations containing 17% poloxamer and 20% Transcutol-P and 10% propylene glycol, respectively, exhibited high values in both adhesiveness and work of adhesion. No significant differences in the permeability and antifungal activity of fluconazole were observed between the formulations. The latter suggests no influence of the gel vehicles on the biological effect of fluconazole. Based on the results, formulations containing 17% poloxamer and 20% Transcutol-P and 10% propylene glycol, respectively, seemed to be promising thermosensitive systems for topical drug delivery.
Jerry Nesamony, Ph.D (Committee Chair)
Kenneth Alexander, Ph.D (Committee Member)
Sai Hanuman Sagar Boddu, Ph.D (Committee Member)
99 p.
Pharmacy Sciences
Poloxamer; Temperature sensitive; Rheology; Mechanical Properties;

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Citations

  • Gandra, S. C. R. (2013). The Preparation and Characterization of Poloxamer-based Temperature-sensitive Hydrogels for Topical Drug Delivery. [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1373375178

    APA Style (7th edition)

  • Gandra, Sarath. The Preparation and Characterization of Poloxamer-based Temperature-sensitive Hydrogels for Topical Drug Delivery. 2013. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1373375178.

    MLA Style (8th edition)

  • Gandra, Sarath. "The Preparation and Characterization of Poloxamer-based Temperature-sensitive Hydrogels for Topical Drug Delivery." Master's thesis, University of Toledo, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1373375178

    Chicago Manual of Style (17th edition)

mco1373375178
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© 2013, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.