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Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil

Majrad, Mohamed Saleh
http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580

Abstract Details

2014, Master of Science (MS), University of Toledo, Pharmaceutical Sciences (Industrial Pharmacy).
The primary goal of this research work was to develop solid lipid nanoparticles (SLNs) containing 5-Flourouracil and to evaluate its effect on various cell lines. The solid lipid nanoparticles were prepared through a new temperature modulated solidification technique developed in our laboratory. Particle size analysis by dynamic light scattering (DLS) and morphology evaluation by transmission electron microscopy (TEM) demonstrated that the SLNs are nanoparticulates. Cytotoxic activity of SLN loaded 5-Fluorouracil showed a decrease in viability when compared to pure solution of 5-FU on PC-3 and Caco-2 cell line. Blank SLN showed no decrease in cell viability when the concentration increased. Biocompatibility studies of SLNs in human RBCs indicated that 5-FU SLN formulations are compatible. Bovine permeability study shows that apparent permeability for 5-FU SLN was 0.000348 cm/s and 1.339 cm/s for 5-FU solution. The preliminary results from various in vitro evaluations suggest that 5-FU loaded SLNs have the potential to be used as an anti-cancer drug delivery system.
Jerry Nesamony (Committee Chair)
Sai HS Boddu (Committee Member)
Ming-Cheh Liu (Committee Member)
125 p.
Pharmaceuticals
Solid Lipid Nanoparticles containing 5-Fluorouracil

Recommended Citations

Citations

  • Majrad, M. S. (2014). Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil [Master's thesis, University of Toledo]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580

    APA Style (7th edition)

  • Majrad, Mohamed. Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil. 2014. University of Toledo, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580.

    MLA Style (8th edition)

  • Majrad, Mohamed. "Quantitative, Qualitative and In Vitro Evaluation of Solid Lipid Nanoparticles Containing 5-Fluorouracil." Master's thesis, University of Toledo, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1404675580

    Chicago Manual of Style (17th edition)

mco1404675580
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© 2014, all rights reserved.
This open access ETD is published by University of Toledo Health Science Campus and OhioLINK.